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       #Post#: 1083--------------------------------------------------
       Sleep Deprivation Causes Inflammation
       By: Road2HardCoreIron Date: September 22, 2022, 4:12 pm
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       How sleep deprivation can cause inflammation
       Inflammation is the body’s natural response to disease and
       injury. When you come down with a respiratory infection or cut
       yourself, your immune system acti­vates white blood cells, which
       in turn release cyto­kines and other inflammatory molecules that
       attack invaders and protect the body’s tissues. When this
       response is temporary, it serves as an effective defense
       mechanism. But when inflammation doesn’t let up, it can
       contribute to the development of heart disease, diabetes,
       stroke, cancer, and Alzheimer’s disease.
       Sleep deprivation is associated with markers of inflammation,
       such as increases in inflammatory molecules—includ­ing
       cytokines, interleukin-6, C-reactive protein (a marker of
       inflammation that’s elevated in people at risk for heart disease
       and diabetes), and others— among people who weren’t sleeping
       well. While these signs of inflammation could be attributed to
       other fac­tors—stress, smoking, or obesity, for example—they do
       suggest that sleep deprivation plays a role in the inflammatory
       process. And they could help explain why people who sleep poorly
       are at risk for cardio­vascular disease, high blood pressure,
       and diabetes, among other chronic conditions.
       How does a lack of sleep contribute to inflamma­tion? One theory
       focuses on blood vessels. During sleep, blood pressure drops and
       blood vessels relax. When sleep is restricted, blood pressure
       doesn’t decline as it should , which could trigger cells in
       blood vessel walls that activate inflammation. A lack of sleep
       might also alter the body’s stress response system.
       In addition, a sleep shortfall interferes with the normal
       function of the brain’s housecleaning system, termed the
       glymphatic system (not to be confused with the lymphatic system
       in the rest of the body). In the deepest sleep phases,
       cerebrospinal fluid rushes through the brain, sweeping away
       beta-amyloid protein linked to brain cell damage. Without a good
       night’s sleep, this housecleaning process is less thorough,
       allowing the protein to accumulate—and inflamma­tion to develop.
       Then, a vicious cycle sets in. Beta-amy­loid buildup in the
       brain’s frontal lobe starts to impair deeper, non-REM slow-wave
       sleep. This damage makes it harder both to sleep and to retain
       and consolidate memories.
       Just one night of lost sleep can keep beta-amyloid levels higher
       than usual. The problem is not so much a single night’s poor
       sleep, which you can compensate for, but a cumulative pattern of
       sleep loss, leading to decreases in the structural integrity,
       size, and function of brain regions like the thalamus and
       hip­pocampus, which are especially vul­nerable to damage during
       the early stages of Alzheimer’s disease.
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