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#Post#: 653--------------------------------------------------
Tofisopam
DIR By: Road2HardCoreIron
Date: May 18, 2022, 7:51 pm
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Tofisopam is generally being accepted as a replacement for
Etizolam.
Tofisopam is an atypical benzodiazepine tranquilliser drug. It
is currently used in Russia, Japan, and several European
countries to treat various psychiatric conditions (mainly
anxiety disorders). Several studies also suggests that Tofisopam
does have antipsychotic effect.
One of the biggest advantages of Tofisopam over conventional
benzodiazepines is that it does not cause sedation and is not
addictive, because of the structural differences.
Tofisopam has unique chemical structure, which determines its
pharmacological effects that are differs from that of other
benzodiazepine tranquillisers. Tofisopam is not a GABA receptors
agonist does not binds to benzodiazepine receptors.
It is suggested that a possible target of action of
2,3-benzodiazepines is the opioid signal transduction. This
suggestion is consistent with the results of animal studies,
which shown that 2,3-BZDs potentiate the effects of opioid
agonists, and their behavioural effects were inhibited by
induced state of opioid tolerance.
Besides having anxiolytic action, Tofisopam has mild stimulating
effect. Studies suggest that Tofisopam increase the sensitivity
of central dopamine receptors, as it is shown to potentiate the
effects of dopaminergic stimulants.
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