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What is DAYVIGO?
By: Road2HardCoreIron Date: June 16, 2024, 11:48 am
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Dayvigo
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Dayvigo
Generic name: lemborexant
Dosage form: oral tablet
Drug class: Miscellaneous anxiolytics, sedatives and hypnotics
Medically reviewed by Philip Thornton, DipPharm. Last updated on
Apr 4, 2023.
Uses
Warnings
Before taking
Dosage
Side effects
Interactions
FAQ
What is Dayvigo?
Dayvigo (lemborexant) is a sleeping pill that helps people who
have trouble falling or staying asleep to sleep better. It helps
you fall asleep faster and stay asleep for longer.
Dayvigo belongs to a class of drugs known as orexin antagonists.
Dayvigo works by blocking orexin receptors (OX1R and OX2R),
which prevents orexin A and B from binding to them. Orexin A and
B are part of the orexin neuropeptide signaling system and one
of their roles is to promote wakefulness. Blocking them from
their receptor binding sites is thought to help suppress the
urge to wake up. This class of drugs works differently from
benzodiazepines which have been used to treat insomnia for many
years.
Dayvigo is a schedule IV federally controlled substance (CIV)
because it can be abused or cause dependence. Selling or giving
away Dayvigo may harm others and is against the law.
Dayvigo was first approved by the US Food and Drug
Administration in 2019.
What is Dayvigo used for?
Dayvigo is a prescription medicine used to treat adults who have
trouble falling or staying asleep (insomnia).
It is not known if this medication is safe and effective in
children under the age of 18 years.
Important information
Dayvigo may cause serious side effects including:
Decreased awareness and alertness. The morning after you take
this medication, your ability to drive safely and think clearly
may be decreased. You may also have sleepiness during the day.
Do not take more than prescribed.
Do not take unless you are able to stay in bed for a full night
(at least 7 hours) before you must be active again.
Take right before going to bed.
See “What are the possible side effects of Dayvigo?” below for
more information about side effects.
Who should not take Dayvigo?
Do not take Dayvigo if you fall asleep often at unexpected times
(narcolepsy).
Dayvigo pregnancy and breastfeeding warnings (more detail)
What should I tell my doctor before taking Dayvigo?
Before taking Dayvigo, tell your healthcare provider about all
of your medical conditions, including if you:
have a history of depression, mental illness, or suicidal
thoughts.
have a history of drug or alcohol abuse or addiction.
have a history of a sudden onset of muscle weakness (cataplexy).
have a history of daytime sleepiness.
have lung problems or breathing problems, including sleep apnea.
have liver problems.
How should I take Dayvigo?
Take Dayvigo exactly as your healthcare provider tells you to
take it.
Only take one time each night, right before going to bed.
Only take when you can stay in bed for a full night (at least 7
hours).
Dayvigo may take longer to work if you take it with or soon
after a meal.
Do not increase your dose without talking to your healthcare
provider first. Call your healthcare provider if your insomnia
(sleep problem) worsens or is not improved within 7 to 10 days.
This may mean that there is another condition causing your sleep
problem.
What happens if I miss a dose?
If you forget to take your dose of Dayvigo right before going to
bed, skip that dose unless you can still stay in bed for at
least 7 hours (a full nights sleep) after taking it. If you do
not remember in time, wait until your next dose is due the
following night. Do not take a double dose if you miss a dose.
What happens if I overdose?
If you take too much Dayvigo, call your healthcare provider or
go to the nearest hospital emergency room right away.
What should I avoid while taking Dayvigo?
Do not drink alcohol while taking Dayvigo. It can increase your
chances of getting serious side effects.
Do not drive, operate heavy machinery, do anything dangerous, or
do other activities that require clear thinking if you take
Dayvigo and have had less than a full night of sleep (at least 7
hours) or if you have taken more than prescribed by your
healthcare provider.
You may still feel drowsy the next day after taking this
medication. Do not drive or do other dangerous activities until
you feel fully awake.
Dosing information
The recommended dose of Dayvigo is 5 mg taken no more than once
per night, immediately before going to bed, with at least 7
hours remaining before the planned time of awakening. The dose
may be increased to 10 mg per night if required.
In patients with moderate liver/hepatic impairment the maximum
dose of Dayvigo is 5 mg. This medication is not recommended in
patients with severe hepatic impairment.
See Full Prescribing Information for further details about
Dayvigo dosing.
Detailed Dayvigo dosage information
What are the side effects of Dayvigo?
Dayvigo may cause serious side effects, including:
see “Important information" above
temporary inability to move or talk (sleep paralysis) for up to
several minutes while you are going to sleep or waking up.
temporary weakness in your legs that can happen during the day
or at night.
complex sleep behaviors such as sleep-walking, sleep-driving,
preparing and eating food, making phone calls, having sex or
doing other activities while not fully awake that you may not
remember the next morning. Call your healthcare provider right
away if you experience a complex sleep behavior.
worsening depression and suicidal thoughts have happened during
treatment with this medication. Call your healthcare provider
right away if you have any worsening depression or thoughts of
suicide or dying.
The most common side effect of Dayvigo is sleepiness.
These are not all of the possible side effects of this
medication. Call your doctor for medical advice about side
effects. You may report side effects to FDA at 1-800-FDA-1088.
Dayvigo side effects (more detail)
Interactions
Tell your healthcare provider about all of the medicines you
take, including prescription and over-the-counter medicines,
vitamins and herbal supplements.
Taking Dayvigo with certain other medicines can cause serious
side effects. Dayvigo may affect the way other medicines work
and other medicines may affect the way this medication works.
Do not take with other medicines that can make you sleepy unless
your healthcare provider tells you to.
Know the medicines you take. Keep a list of your medicines with
you to show your healthcare provider and pharmacist each time
you get a new medicine.
Dayvigo drug interactions (more detail)
Pregnancy and breastfeeding
Tell your healthcare provider if you are pregnant or plan to
become pregnant. It is not known if Dayvigo can harm your unborn
baby.
There is a pregnancy registry for women who are exposed to
Dayvigo during pregnancy. The purpose of this registry is to
collect information about the health of you and your baby. For
more information or to participate in the registry, call
1-888-274-2378. Talk with your healthcare provider about the
risk to your unborn baby if you take this medication during
pregnancy.
Tell your healthcare provider if you are breastfeeding or plan
to breastfeed. It is not known if Dayvigo passes into your
breast milk. Talk to your healthcare provider about the best way
to feed your baby during treatment.
Storage
Store Dayvigo at room temperature between 68°F to 77°F (20°C to
25°C).
Keep out of the reach of children.
What are the ingredients in Dayvigo?
Active ingredient: lemborexant
Inactive ingredients: hydroxypropyl cellulose, lactose
monohydrate, low-substituted hydroxypropyl cellulose, and
magnesium stearate. The tablet film coating contains:
hypromellose 2910, polyethylene glycol 8000, talc, titanium
dioxide, and either ferric oxide yellow for the 5 mg tablet; or
both ferric oxide yellow and ferric oxide red for the 10 mg
tablet.
Dayvigo is distributed by Eisai Inc. Nutley, NJ 07110.
Popular FAQ
Is Dayvigo a controlled substance?
Yes, Dayvigo contains lemborexant, a Schedule IV controlled
substance and may cause sleepiness. People with a history of
abuse or addiction to alcohol or other drugs may be at increased
risk for abuse and addiction to Dayvigo. Do not drink alcohol
while taking Dayvigo due to the risk of serious side effects.
Keep this medicine in a safe place to prevent misuse, abuse or
theft. Selling or giving away Dayvigo to others may be harmful
and is against the law.
Can you drink alcohol while taking Dayvigo?
No, you should not drink alcohol while tasking Dayvigo because
it can increase the side effects of Dayvigo such as drowsiness,
dizziness, affect judgment, or impair memory or comprehension.
Is Dayvigo a sleep medication?
Yes, Dayvigo is a medication to help you fall asleep faster and
stay asleep longer. In Phase III clinical studies at 6 months
time, Dayvigo sleep medication (5 and 10 mg tablets) helped
people fall asleep faster by about 7 to 8 minutes more than a
placebo, an inactive agent (results: Dayvigo 5 mg = 20 min;
Dayvigo 10 mg = 19.2 min; placebo = 27.2 min).
Is there a Dayvigo free trial available?
Yes, you can access a 10-day Dayvigo free trial by printing a
voucher from the Eisai Inc. website. Take the voucher along with
your prescription to the pharmacist. The manufacturer also
offers an Instant Savings Card that can bring your prescription
costs down to as little as $30 per month.
How long does it take for Dayvigo to work?
Dayvigo starts to work right away to help you fall asleep and
stay asleep. In 6-month long studies, people fell asleep an
average in about 20 minutes after taking their dose. Dayvigo may
take longer to work if you take it with or soon after a meal.
Because it works so quickly, only take your Dayvigo dose right
before going to bed. Do not take Dayvigo unless you can stay in
bed for at least 7 hours before you must be active again.
What is Dayvigo's drug class?
Dayvigo (lemborexant) is classified as a dual orexin receptor
antagonist (DORA). It is approved for the treatment of adults
with insomnia who have trouble falling asleep or staying asleep.
Dayvigo works by blocking the wake-promoting neuropeptides
orexin A and orexin B from attaching to their receptors in the
hypothalamus of the brain. Orexin signals in the brain are
thought to play a role in wakefulness.
Does Dayvigo cause weight gain?
Dayvigo has not been shown to cause weight gain in studies
conducted by the manufacturer. The most common side effect of
Dayvigo is sleepiness. Other reported side effects include
headache, abnormal dreams and sleep paralysis. Dayvigo is
prescribed to help adults who have trouble falling or staying
asleep (insomnia).
Is Dayvigo addictive?
References
Food and Drug Administration (FDA) Dayvigo Product Label.
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Drug class: miscellaneous anxiolytics, sedatives and hypnotics
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