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Equipoise (Boldenone) AKA EQ
By: Road2HardCoreIron Date: May 25, 2018, 6:45 pm
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Equipoise (Boldenone)
Overview and History of Equipoise
Equipoise is the brand/trade name for the anabolic steroid
Boldenone, which is an oil-based injectable anabolic steroid
with the Undecylenate ester attached to it for a prolonged
release rate and half-life. It is a derivative of Testosterone
that retains Testosterone’s anabolic strength but exhibits a
reduced androgenic effect in comparison. Equipoise is primarily
a veterinary product, originally intended for use in animals.
Equipoise has gained popularity with bodybuilders and athletes
as a less androgenic form of Testosterone with less Estrogenic
activity than Testosterone as well. Many users enjoy comparing
it to that of Nandrolone (Deca Durabolin), however, this
comparison is a very poor one seeing as though Nandrolone
exhibits different properties than Equipoise and is also a
totally different class of compounds (a 19-nor, also known as a
progestin). However, many consider Nandrolone and Equipoise to
be a solid substitute for one another in any given cycle.
A few interesting facts first about this compound: Equipoise was
in fact developed in 1949, even before Dianabol
(Methandrostenolone), making Equipoise technically the very
first synthetic derivative of Testosterone even before Dianabol
was ever thought of. Furthermore, Dianabol itself is actually
Equipoise (Boldenone) with a methyl group attached to its
17-beta hydroxyl group on the steroid chemical structure (also
known as C17-alpha alkylation) in order to allow it to become
orally bioavailable in the body. Technically, Dianabol
(Methandrostenolone) is actually C17-alpha alkylated Equipoise.
It would have been considered an oral form of Equipoise, but the
methylation at the 17th carbon atom changed enough of the
properties of the compound that it was considered a totally
different anabolic steroid analogue, and named
Methandrostenolone (Dianabol). If pictures of the chemical
structures of Equipoise and Dianabol were laid out side by side,
one would easily be able to tell the exact same chemical
structure between the two, with the exception of the methyl
group affixed to the 17th carbon on the Dianabol chemical
structure. It is very evident that these two anabolic steroids
are essentially the exact same.
Although Equipoise was first developed in 1949, it was not until
the 1960s when this compound would be finally released and
marketed as Parenabol. Between 1949 and its release in the
1960s, Ciba had toyed around with Equipoise by attempting to
affix different esters onto it in order to augment its half-life
and release rates. The final conclusion was that it would be
released with the Undecylenate ester attached to it, and the
final preparation was that of Boldenone Undecylenate. Following
the release of Parenabol, various clinical trials and testing of
this compound was conducted in the late 1960s and early 1970s
with the goal in mind to use it as a lean mass promoting and
preserving anabolic steroid in order to treat individuals
suffering from any condition in which wasting and weight loss
were symptoms, as well as an osteoporosis treatment. Parenabol
saw very little application or use following its release, and
towards the end of the 1970s, it was removed from the market and
discontinued.
Squibb would then pick up the patents for this anabolic steroid
and re-release Boldenone under the name Equipoise as a
veterinary anabolic steroid meant primarily for application in
horses but is also intended for use in other animals. Equipoise
is well known for its lean mass increases as well as its
appetite-stimulant effects, which is an effect common among
nearly all anabolic steroids. However, Equipoise tends to
stimulate the appetite to far greater degrees than any other
anabolic steroids. Although the manufacture and marketing of
Equipoise has changed many hands over the years, it still
remains available on the American market as well as
internationally with plenty of generic brands as well as actual
brand names available.
Chemical Characteristics of Equipoise
As previously mentioned, Equipoise is a synthetic derivative of
Testosterone where it has been modified at carbon 1 and carbon 2
on the steroid structure, where double-bonds have been added
between these two carbon atoms. This is what is known as the
modification that is responsible for reducing Equipoise’s
affinity for interaction with the aromatase enzyme (the enzyme
responsible for the conversion of androgens into Estrogen). As a
result, its Estrogenic activity is regarded to be lower than
Testosterone. Equipoise is Boldenone with the Undecylenate ester
attached to it. Specifically, ‘Undecylenate’ is Undecylenoic
acid, but once bound to Boldenone it is properly referred to in
chemistry as an ester bond (or ester linkage). Undecylenoic acid
is chemically bonded to the 17-beta hydroxyl group on the
Boldenone structure. The addition of this ester augments the
hormone’s release rate and half-life to favor a longer window of
release. The primary reason for the augmentation of its
half-life and release rate is because once Boldenone
Undecylenate enters the bloodstream, enzymes work to break the
bond between the ester and the hormone, which takes a varying
amount of time. The end result is that of the ester being
removed from the hormone by these enzymes, and the result
following this is pure Boldenone that is free to do its work in
the body. This process of enzymes removing the ester from the
hormone to which it is attached is what is responsible for the
slower release rates. When the Undecylenate ester is attached to
Boldenone, creating Boldenone Undecylenate, the half-life of
Boldenone is now extended to 14 days, providing a slower release
and activity of the hormone than the hormone otherwise would
without this ester.
Additionally, as noted near the beginning of this section,
Equipoise and Dianabol are structurally identical with the only
difference between the two being that Equipoise contains a the
Undecylenate ester attached to its 17-beta hydroxyl group, and
Dianabol instead contains a methyl group attached to its 17-beta
hydroxyl group. Dianabol contains the methyl group (also known
as C17-alpha alkylation) in order to prevent it from being
metabolized and broken down by the liver through oral ingestion.
Aside from these modifications, the two hormones are exactly
identical and would be considered the exact same compounds.
However, both of these hormones act significantly different from
one another in the body, which is a very strong indication that
the addition of a methyl group (C17-alpha alkylation) to the
17th carbon does more than just affect the hormone’s resistance
to breakdown in the liver – it actually changes the effects and
properties of the anabolic steroid.
Properties of Equipoise
Equipoise being a derivative of Testosterone grants it many of
the same properties. For one thing, it possesses the exact same
anabolic strength rating (100), and it is also an aromatizable
anabolic steroid, which means that Equipoise can and does
convert into Estrogen in the body through interaction with the
aromatase enzyme. However, its double-bond modifications between
carbons 1 and 2 reduce its affinity for the aromatase enzyme,
granting it a lower rate of aromatization and therefore a lower
Estrogenic activity in the body.
What this means is that Equipoise will still convert into
Estrogen, but at a far less significant amount than its parent
hormone Testosterone. Although this is a very comforting fact
and a pleasing property, the issue of Estrogenic side effects is
still an issue and should not be ignored by any users.
Therefore, individuals can expect not an elimination of
potential water retention, but a vast difference in a reduction
of it from Equipoise alone. Although at sensible and moderate
doses, Equipoise should not exhibit bloating or any other
estrogenic effects (depending on user sensitivity), the risk of
these Estrogenic side effects will indeed increase as higher and
higher doses of Equipoise are used. Increasing doses will mean
increased rates of aromatization of the anabolic steroid into
Estrogen.
Equipoise itself possesses a low androgenic strength rating
(lower than its progenitor hormone Testosterone), which should
be pleasing to individuals whom are sensitive to any number of
androgenic side effects. Overall, individuals utilizing
Equipoise can expect the same anabolic size, strength, and mass
gains that would come from Testosterone with a lower incidence
of Estrogenic activity and androgenic side effects. This means
that gains from Equipoise itself should, for the most part, be
fairly solid lean mass gains with minimal water retention
(depending on dose) and would be a perfect addition to any
bulking or lean mass cycle. It would even work as an appropriate
replacement for Nandrolone in any stack.
Equipoise Side Effects
As previously mentioned, Equipoise expresses a lesser degree of
estrogenic activity in the body than Testosterone itself.
Studies have demonstrated that approximately half of the
aromatization rate is experienced in the body with EQ as
compared with Testosterone. Thus, the magnitude of
Estrogen-related side effects with Equipoise should be
significantly lower than Testosterone, but it is important to
note that its estrogenic activity is still higher than
Nandrolone (Deca) by a small degree. Of course, if dosages rise,
then aromatization (and subsequently, estrogenic effects) will
rise in proportion. Usually Equipoise dosages rising above 200 –
400mg per week will result in observable increases in estrogenic
side effects. Anti-estrogens and aromatase inhibitors may be
necessary in these cases to stave off and ward off these side
effects. Estrogenic side effects can include: water retention
and bloating, increases in blood pressure (resultant from water
retention), increased fat gain/retention, and potential
development of gynecomastia.
Androgenic side effects, although much lesser than Testosterone,
are still a possibility with Equipoise. Although Equipoise
interacts with the 5AR (5-alpha reductase) enzyme, which is the
enzyme responsible for the conversion of Testosterone into the
stronger androgen DHT (Dihydrotestosterone), it does not convert
into DHT but instead converts into Dihydroboldenone (DHB).
Although it converts into DHB, studies have found Equipoise to
undergo this conversion at a much lower rate than the conversion
of Testosterone into DHT. Androgenic side effects can include:
increased oily skin (sebum secretion), increased acne formation
(linked to sebum secretion), bodily and facial hair growth, and
the increased risk of experiencing male pattern baldness (MPB)
if the individual possesses the genetic predisposition for it.
Equipoise is not liver toxic, and it does express the same
degree of cardiovascular risks and endogenous Testosterone
production suppression as most anabolic steroids.
Dosing and Administration of Equipoise
Medical Equipoise dosages and guidelines are nonexistent due to
the fact that Equipoise is not currently approved for human use
as a medicine. Although it was first utilized very briefly
during the 1970s as a human grade medicine, this is no longer
the case.
In the bodybuilding and athletic circles, beginner Equipoise
dosages are generally in the range of 300 – 500 mg per week,
followed by 500 – 700mg per week for intermediate dosages.
Equipoise dosages are usually very similar to Testosterone, and
venturing higher than the intermediate range is extremely rare,
especially when the user is utilizing Equipoise alongside other
compounds within a cycle, which should normally be the case.
Female anabolic steroid users might find Equipoise a suitable
compound due to its considerably lower androgenic capabilities
than Testosterone. In this case, females should find it
acceptable to use 50 – 75mg per week. However, an issue that may
present itself is Equipoise’s very long half-life of 14 days,
which will undoubtedly manifest as a slow reduction of blood
plasma levels. With this comes a slow elimination of the
compound from the body, and this can be an issue when/if
virilization signs and symptoms appear in female users and
prompt discontinuation of the drug is paramount.
Being that its half-life is 14 days, it is ideal to split up the
weekly dosage into two administrations spaced evenly throughout
the week (for example, 500mg per week administered as 250mg on
Monday and 250mg on Thursday).
Equipoise Cycles and Uses
EQ cycles are usually run as mass gaining cycles that always
involve the use of at least Testosterone in some form (usually
the long esters of Testosterone, in order to match-up with EQ’s
half-life). This is usually done with either Testosterone
Enanthate or Testosterone Cypionate. Equipoise cycles are also
normally run for much longer cycle lengths than most other
compounds, due to the fact that its longer half-life provides a
slower release and peak-time for effects to be seen.
Beginner Equipoise cycles normally involve the use of
Testosterone Enanthate (or Cypionate) at around 300 – 500mg per
week alongside Equipoise at about 400mg per week. The cycle
should be run for a total of 14 weeks. This should provide the
user with a considerable amount of mass gains over the long
term. Intermediate Equipoise cycles can involve the added use of
an oral compound, usually Dianabol (Methandrostenolone) at about
25mg per day. Testosterone Enanthate (or Cypionate) in this case
can be reduced to 100mg per week in order to merely maintain
normal physiological function, and Equipoise can be run at about
400 – 600mg per week. The Dianabol in this case is run from
weeks 1 – 4, and the total cycle length is 12 weeks.
Advanced Equipoise cycles usually do not see the use of EQ at
dosages above 600mg per week. Much like the intermediate
Equipoise cycles, Testosterone can be run at TRT (Testosterone
Replacement Therapy) dosages of around 100mg per week, and an
advanced compound can be used alongside everything, such as
Trenbolone Enanthate at 400mg per week. Total cycle length would
be 12 weeks.
Equipoise Legality
USA: In the United States, Equipoise is classified as a Schedule
III drug in the Controlled Substances Act whereby possession and
use of EQ or any Testosterone product without a valid
prescription would be considered a felony. Needless to say,
trafficking, importation, and the purchase of EQ or any anabolic
steroid is a criminal act.
UK/England: In the United Kingdom, Equipoise falls under
Schedule IV, whereby possession and use of Equipoise without a
physician’s prescription is legal for personal use. Importation
of Equipoise for personal use without a prescription is also not
a felony.
Canada: Canadian law is similar to the UK, where it is a
Schedule IV drug, and as such, possession and use of Equipoise
for personal use without a valid physician’s prescription is not
a felony and is legal. However, trafficking of the substance is
a felony.
These are 3 examples of the current state of laws under which EQ
falls into within 3 major countries in the world. Whichever
route one decides to acquire Equipoise through, he or she must
be aware of the legality and laws surrounding it in whichever
country the person resides. It is important to research
beforehand in order to make the appropriate decisions and what
to expect. Ignorance of the law is no excuse.
How to Buy Equipoise
Equipoise is moderate in popularity and usage among athletes and
bodybuilders, and it is very rare that a source or vendor would
not carry this product. No pharmaceutical grade for-human-use
Equipoise products currently exist. Therefore, on the anabolic
steroid black market, there will only be veterinary and UGL
(Underground Laboratory) grade Equipoise for those looking to
buy it. It is available in a vast variety of different forms,
concentrations, dosages, and vials sizes – probably more so than
any other anabolic steroid available. It would therefore be
futile to list every single one here. Equipoise is available,
for example, in 10ml, 50ml, 100ml, 250ml, and even 500ml vials.
It is commonly concentrated at 200mg/ml, although some
underground laboratories have manufactured 250mg/ml Equipoise
products, and even higher concentrations exist.
Those looking to buy EQ will usually run into the following
price ranges: on the highest end, EQ can sell for $150 – $170
for a single 10ml vial containing 200mg/ml of underground
quality. At its low end, underground Equipoise can be found for
$60 – $100 for the same type of product (10ml vial containing
200mg/ml). Veterinary Equipoise at its highest price range can
be found for $17 – $20 per 1ml glass ampoule containing 50mg/ml.
At its lowest price range, the same veterinary product can be
fou
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