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Masteron
By: Road2HardCoreIron Date: May 25, 2018, 6:40 pm
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Overview and History of Masteron
Masteron is the trade name for the anabolic steroid
Drostanolone. Materon is an injectable oil-based anabolic
steroid, and is derived from Dihydrotestosterone (DHT), which
makes Masteron a member of the DHT-derived family of anabolic
steroid derivatives and analogues. Essentially, all anabolic
steroid analogues and derivatives are all modifications in one
way or another of the three primary anabolic steroids naturally
found in all humans: Testosterone, Dihydrotestosterone, and
Nandrolone. In this case, Masteron’s progenitor (or parent)
hormone is Dihydrotestosterone. Other anabolic steroids that
belong in this family of DHT-derivatives include: Anavar,
Winstrol, Anadrol, Primobolan, and various others. Masteron is
not regarded as a very strong anabolic steroid but neither is it
a weak one. Its anabolic strength is generally regarded as
moderate at best (anabolic rating of 62 – 130), while its
androgenic strength is fairly low (25 – 40). This demonstrates a
stark difference when compared to Testosterone, which is the
number one natural and original anabolic steroid, and is used as
the reference measuring bar by which all other anabolic steroids
are compared to and measured against. Testosterone in comparison
holds an anabolic and androgenic strength rating of 100 for both
respectively.
Masteron’s details (as Drostanolone) were first released and
published in 1959[1]. The origins of this compound are quite
interesting, as Syntex had synthesized and developed this
anabolic steroid. Syntex was also known for the development of
other popular anabolic steroids as well, such as Anadrol and
Methyldrostanolone (AKA Superdrol). It would not be until about
10 years later after the publishing of its details that Masteron
would finally be released onto the market. Lilly and Syntex had
worked together in the development and marketing of different
pharmaceuticals, and both companies had an agreement that both
entities would share research and development (R&D) resources
and costs with the trade-off that one of the companies would
obtain the rights to the drug. It was Lilly that ended up
marketing Masteron under the brand name known as Drolban on the
American market. Syntex also marketed this anabolic steroid,
only they would look after its marketing and distribution on the
international market instead.
MASTABOL British Dragon Pharma 100mg/ml 10ml Vial
Masteron was approved by the FDA at first as an antineoplastic
agent in the treatment of female breast cancer patients.
Masteron in particular fit very well into this role, as its
lower and weaker androgenic strength rating in comparison to
Testosterone could prove to be very beneficial in female users,
as the incidence of virilization symptoms would be less
prominent with Masteron than many other anabolic steroids which
are known to possess strong androgenic strength ratings. Even
the prescription information and guidelines expounded this fact,
stating that there is far less of a probability of developing
virilization with Masteron in comparison to equal Testosterone
Propionate doses. However, the problem here was that the initial
prescription guidelines for females was that of 300mg weekly of
Masteron, which evidently proved to be too high of a dose for
females as evidenced by the fact that virilization did occur in
many patients at that dose. Virilization had also become an
issue in female patients that had been administered Masteron in
the long term.
Masteron’s popularity with bodybuilders and athletes did not
begin until the 1970s and increased into the 1980s. As more
effective breast cancer treatments were discovered and
developed, Masteron began to lose its value in the medical
field, and many different pharmaceutical manufacturers began to
slowly discontinue sale and production of this compound during
this time. Drolban itself was officially pulled from the
American market in the late 1980s, and two other branded
Masteron preparations were soon after pulled from the market as
well. Masteron today still remains on the list of approved
medications, but it is not currently being manufactured, and
therefore not being sold on American (or any Western) markets.
Chemical Characteristics of Masteron
The specific name for Masteron is actually Dromostanolone
(Drostanolone was a slightly more abbreviated name given to the
compound shortly after its release). As mentioned previously, it
is a modified derivative of DHT (Dihydrotestosterone), placing
it into the family of DHT-derivatives and analogues. Masteron is
a modified form of DHT, where a methyl group at the 2nd carbon
(known as carbon alpha) atom. This modification is what is known
to be responsible for the slight anabolic strength increase in
comparison to Testosterone. This methyl group addition increases
the anabolic strength by way of granting Masteron an increased
resistance to being metabolized into inactive metabolites by the
enzyme 3-hydroxysteroid dehydrogenase. This enzyme is present in
large quantities in muscle tissue, and is the enzyme that serves
to metabolize any DHT that enters muscle tissue into two
inactive metabolites: 3-Alpha Androstanediol and 3-Beta
Androstanediol that are non-anabolic what so ever in muscle
tissue. This is therefore the reason as to why DHT is not
anabolic in muscle tissue at all, and many chemists and
biologists believe that if the enzyme 3-hydroxysteroid
dehydrogenase did not exist in muscle tissue, that DHT would
actually be a very potent and powerful anabolic steroid.
In any case, Masteron’s methyl group addition to alpha carbon 2
effectively eliminates its ability to be metabolized by this
enzyme.
There exist two different variants of Masteron: Drostanolone
Propionate, and Drostanolone Enanthate. The most popular variant
is the Propionate variant, followed in popularity by the
Enanthate variant. The explanation here will use Drostanolone
Propionate as the example. Specifically, ‘Propionate’ is
Propanoic acid, but once bound to Masteron it is properly
referred to in chemistry as an ester bond (or ester linkage).
Propanoic acid is bonded to the 17-beta hydroxyl group on the
Drostanolone (Masteron) chemical structure. The addition of this
ester modifies the hormone’s half-life and release rate,
providing a much longer extended release and half-life than if
the hormone was not esterified. The primary reason for the
augmentation of its half-life and release rate is because once
Drostanolone Propionate enters the bloodstream, enzymes in the
body will break the bond between the ester and the hormone,
which takes varying amounts of time (the time taken for the
bonds to be broken is dependent on the size of the ester – the
longer and larger it is, the longer it will take). The end
result is that the ester is removed from the hormone by enzymes,
and what is left is pure Masteron (or any anabolic steroid that
was previously esterified) that is now free to do its work in
the body. This process of enzymes cleaving off the ester from
the Testosterone molecule is what is responsible for the slower
release rates and extended half-lives.
As a result, Drostanolone Propionate possesses a half-life of
2.5 days, and Drostanolone Enanthate possesses a half-life of 10
days. Esterification does nothing to modify the effects and
characteristics of the hormone aside from augmenting the
hormone’s release rates and half-lives.
Properties of Masteron
Because Masteron is a DHT-derivative, it retains some of the
same characteristics as its parent hormone, one of which is its
inability to interact with the aromatase enzyme. The aromatase
enzyme is the enzyme responsible for the conversion of androgens
into Estrogen, of which Masteron is invulnerable to this
process. Therefore, Masteron will exhibit no Estrogenic side
effects at any dose, making Masteron completely void of the
following risks: water retention and bloating, elevated blood
pressure (as a result of water retention), possible fat
gain/retention, and gynecomastia. Individuals using Masteron
will only experience lean mass gains without the addition of
water weight, which would otherwise serve to create a very
puffy, soft, and bloated looking physique. It is therefore an
anabolic steroid preferred by the majority of bodybuilders and
athletes as a ‘cutting’ compound considered very useful for
pre-contest cycles and fat loss and cutting phases.
Due to its low to moderate anabolic strength, Masteron is not
regarded as being a very good mass addition or bulking compound,
and in fact many experienced anabolic steroid users suggest that
due to its higher price and its moderate anabolic strength, it
is only of real value to competitive bodybuilders who wish to
achieve a very hardened and ‘chiseled’ look to the physique once
on-stage in a show. When stacked with other particular
compounds, Masteron has been shown to bring out a ‘ripped’
physique to an even greater deal. However, these ‘hardening’
properties of Masteron do not exhibit themselves in the user
unless he or she possesses a low enough body fat percentage to
be able to allow these hardening effects to become visible. This
leads to the next major property of Masteron.
Masteron has been demonstrated as being a moderate aromatase
inhibitor, as well as possibly acting to block Estrogen at
receptor sites on breast tissue[2] [3]. This is the reason for
Masteron’s original and primary use as an advanced breast cancer
treatment drug. This is also the reason as to why Masteron has
been explained by many experienced users as having a ‘hardening’
and ‘chiseling’ effect on the physique when the body is very
lean (under 10% body fat). Masteron works to inhibit the
aromatase enzyme, thereby eliminating the ability for estrogen
to be formed from aromatizable anabolic steroids through the
process of aromatization. Essentially, this effectively reduces
any water retention as Estrogen levels continue to decline from
increasing numbers of disabled aromatase enzymes.
Masteron Side Effects
Masteron is regarded by the bodybuilding community as being one
of the ‘mild’ anabolic steroids when it comes to side effects.
This is due in large part to the fact that Masteron is a
DHT-derivative. Having been derived from DHT, it therefore
possesses all of the same (or similar) attributes and features
that DHT does. This includes the inability to interact with the
aromatase enzyme, and therefore be completely void of any
Estrogen-related side effects.
As previously mentioned, Masteron is totally void of any
estrogenic side effects by virtue of the fact that it is a
DHT-derivative. Not only does it completely avoid aromatization
(conversion into Estrogen), evidence suggests that it behaves as
a mild aromatase inhibitor as well. Side effects resultant of
Estrogen buildup (such as water retention, bloating, fat
retention and gain, and the development of gynecomastia) are
completely avoided or reduced with the use of Masteron.
Though Masteron holds a weaker androgenic strength rating than
Testosterone itself, androgenic side effects are still indeed
possible with this compound, especially among those who may be
particularly sensitive. Masteron side effects that include
androgenic side effects include: an increase in oily skin (as a
result of increased sebum production/secretion), increased
facial hair and bodily hair growth, as well as the increased
risk of triggering MPB (Male Pattern Baldness) in those that are
genetically sensitive or predisposed to it. Virilization (the
development of male characteristics in women) is also a risk
with female use, though its use in female breast cancer patients
should attest to its acceptable nature as a female-use compound.
Masteron side effects in particular include greater negative
impacts on cholesterol and the cardiovascular system than some
other compounds. This is largely due to Masteron’s
anti-estrogenic capabilities in the body. Its ability to reduce
serum levels of Estrogen results in measurable reductions in HDL
(‘good’) cholesterol, and increases LDL (‘bad’) cholesterol[4].
Masteron exhibits no hepatotoxicity (liver toxicity), but like
any anabolic steroid, it does contribute to suppression/shutdown
of the HPTA, thereby reducing endogenous production of
Testosterone.
Masteron Cycles and Uses
Masteron cycles tend to be quite limited in their dynamic and
application. This is because of the nature of the compound being
unfavorable for bulking, strength gain, and the like.
Unfortunately, as a cutting or fat loss agent, there are much
better anabolic steroids in existence at the disposal of the
individual than Masteron. Therefore, the only particular
Masteron cycles that bodybuilders tend to use involve
pre-contest and cutting / fat-loss cycles. Even in cutting or
fat loss cycles, Masteron is usually not a key-role compound
involved.
The cycle length of Masteron cycles are usually in the range of
8 – 10 weeks, mostly due to its short-ester nature. Some
bodybuilders will elect to utilize Masteron only within the
final 2 – 4 weeks of a cycle leading up into a show or a
photoshoot, only to gain advantage of its physique enhancement
abilities. This generally looks like a cycle performed for 10
weeks, with compounds such as Testosterone Propionate,
Trenbolone Acetate, and Anavar being used. Towards the 6 or
8-week mark of said cycle, Masteron would be included into the
mix (alongside perhaps a removal of one of the other compounds),
and run right to the end of the 10th week.
For more traditional Masteron cycles, its use as a fat loss /
cutting compound would involve consistent use over a 8 – 10 week
period alongside compounds of a similar nature, such as
injectable Winstrol, Testosterone Propionate, and perhaps
Trenbolone Acetate or the oral variant of Winstrol.
Masteron Dosages and Administration
Within the medical arena, Masteron was utilized in the treatment
of female breast cancer patients. Towards this end, prescription
guidelines for Masteron dosages would call for 100mg three times
per week, for a grand total of 300mg/week. The duration of this
treatment was recommended to be 8 weeks at a minimum. By the 8 –
12-week mark, the physician would provide an assessment of the
patient and their progress, and based upon the progress and the
prognosis, Masteron may be utilized indefinitely in the
treatment of the cancer. It is worth noting that 300mg/week, in
retrospect, is far too much for female use and was even admitted
somewhat by the medical establishment due to the observation of
virilization becoming a frequent issue among patients. Female
athletes and bodybuilders would find 50 – 100mg per week a safe
and acceptable dosage.
For athletic and bodybuilding purposes for male users, Masteron
dosages are in the range of 200 – 400mg per week, and the lower
end of this range (200mg) is commonly utilized for pre-contest
preparation and cycles. Because of the specialization of
Masteron being an aesthetic physique enhancing compound,
intermediate and even advanced users tend not to venture higher
than the 400mg/week mark. It must be remembered that Masteron is
a weak compound where the addition of strength, mass, and muscle
is concerned, and there are more effective (and cheaper)
compounds for this purpose.
How to Buy Masteron and Legality
Masteron is not as popular as many other anabolic steroids, and
would be considered low-moderate in popularity on the market. It
is, however, a staple in any source/seller’s inventory of
products for sale. Those looking to buy Masteron will find that
it is quite the expensive anabolic steroid as well, and is by no
means a cheap compound, even as an underground product.
Pharmaceutical grade Masteron is extremely rare and almost
nonexistent on the market, leaving nearly all Masteron products
available for sale as underground lab (UGL) products. The only
pharmaceutical grade Masteron product that technically still
exists is known as Dromostan, manufactured by Xelox Company out
of Mayanmar. However, this product is neither Drostanolone
Propionate or Enanthate. Instead, it is Drostanolone base, an
un-esterified variant of Drostanolone. To most athletes and
bodybuilders, this is essentially a useless product. Although it
can still be used if acquired, the lack of an ester would result
in the half-life of Drostanolone to be extremely short and
therefore require injections possibly at least once per day and
as many as multiple times per day.
Depending on the source, Masteron of underground origin will
generally range from $170 – $230 for a 10ml vial that is in a
concentration of 100mg/ml. Some cheaper sources may have
Masteron available (in the same 10ml 100mg/ml format) in the
range of $80 – $120. Once again, these are all strictly
underground products, as pharmaceutical grade Masteron is pretty
well nonexistent on the anabolic steroid black market.
Masteron Information:
Masteron (Drostanolone, Dromostanolone)
Chemical Name: 2alpha-methyl-androstan-3-one-17beta-ol,
2alpha-methyl-dihydrotestosterone
Molecular Weight: 304.46 g/mol
Formula: C20H32O2
Original Manufacturer: Syntex and Eli Lilly
Half Life: 4.5 days (Propionate), 10 days (Enanthate)
Detection Time: 2 weeks
Anabolic Rating: 62 – 130
Androgenic Rating: 25 – 40
Masteron Refer
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