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Modiwake The Rise Of The Smart Drug
By: Road2HardCoreIron Date: May 25, 2018, 6:35 pm
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Modafinil: The Rise of Smart Drugs
The core of biohacking is finding tricks and tools that cause a
big impact with very little effort. Call it enlightened laziness
or the relentless pursuit for personal perfection, if there is
any difference between them. It’s time to write about Modafinil,
the performance-enhancing smart drug that belongs in your bag of
biohacker tricks, at least some of the time. This post shares
the experience of several people who use it, including
first-time users and an interview with a biomedical engineer
who, like me, is a long-time Modafinil user. Read to the end for
warnings.
What is modafinil?
Modafinil is a smart drug, also known as a nootropic. It
enhances your cognitive function in a variety of ways (more on
that in a second). There are plenty of smart drugs, but
modafinil stands in a class of its own for a few reasons:
It’s not a stimulant. Modafinil acts sort of like a stimulant,
but it’s actually a eugeroic – a wakefulness-promoting agent. It
doesn’t make you speedy or jittery like most classical
stimulants do. Modafinil also doesn’t have a crash or
withdrawal, the way many smart drugs do.
It’s not addictive.[1] In fact, modafinil can help people kick
addictions.[2]
It has few to no side effects. Modafinil is very safe. I’ve
hacked my brain with neurofeedback so much that I don’t see much
of a benefit from modafinil now, but I took it every day for 10
years and saw no problems of any kind with it during that time.
It works. Really well. Have you ever seen the movie Limitless
with Bradley Cooper? It’s based on modafinil. This stuff gives
you superhuman mental processing, with few to no downsides.
How modafinil enhances your brain and mood
Unlike some smart drugs, there’s a good deal of evidence to back
up the effects of Modafinil.
It has been shown to increase your resistance to fatigue and
improve your mood.[3]
In healthy adults, modafinil improves “fatigue levels,
motivation, reaction time and vigilance.”[4]
A study published by the University of Cambridge found Modafinil
to be effective at reducing “impulse response”, i.e., bad
decisions.[5]
Modafinil even improves brain function in sleep deprived
doctors.[6]
There is some evidence Modafinil only helps people with lower
IQ,[7] but after years of experimenting (and upgrading my IQ),
it doesn’t feel that way.
Is modafinil safe?
Modafinil is not addictive.[8][9] It has a risk of abuse,
however – some people use it to stay up for way too long, which
will probably make you sick.
There is an extremely rare condition (about 5 cases per million
people[10]) called SJS, or Stevens-Johnson Syndrome, in which
people with genetic susceptibility can develop a dangerous life
threatening rash. SJS is most often triggered by antibiotics,
followed by analgesics, cough and cold medication, NSAIDs,
psychoepileptics, and antigout drugs. Cocaine, phenytoin, and
modafinil can trigger it. More info here.
Even though the risk is low, you might want to get a genetic
test before you use any of those drugs, including Modafinil. If
you have one of these SNPs, you may have an increased risk, and
to have the lowest risk, there are *a lot* of drugs you should
avoid including some basic antibiotics…and Modafinil.
HLA-B*5801
HLA-B*1502
HLA-B*5801
HLA-B*44
HLA-A29<
HLA-B12
HLA-DR7
HLA-A2
HLA-B*5801
HLA-A*0206
HLA-DQB1*0601
I never got tested because the incidence is so low. The full
results are not available on the affordable genetic testing site
23andme, but you can ask your doctor to order at least some of
these tests through Quest Diagnostics. I don’t know anyone who
has gotten these tests, for what it’s worth.
How to dose modafinil
For most healthy people, 30-50 mg of modafinil will be plenty.
It lasts 6-8 hours; take it in the morning, with or without
food. I should say that modafinil is a prescription drug; you
can talk to your doctor about it. There are places you can get
it online; I don’t want to link to them because of legal
issues…but you may be able to find a source. Biohack
responsibly, of course.
Alternatives to modafinil
Not everyone’s game to take a prescription drug for cognition.
Racetams and microdoses of nicotin
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