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Rimobolan and Primobolan Info
By: Road2HardCoreIron Date: April 6, 2024, 6:11 pm
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Primobolan (Methenolone)
Overview and History
Primobolan is the trade name for the anabolic steroid
Methenolone (also written as Metenolone). It is available in
both an injectable oil-based format, as well as an oral form.
Injectable Primobolan is known as Methenolone Enanthate, and the
oral format is known as Methenolone Acetate. It is a very
well-known and popular anabolic steroid due to its very mild
nature as both an anabolic and an androgenic compound. It is
often compared to Anavar, a similar anabolic steroid but the
difference between the two is very distinct – Anavar possesses a
far greater anabolic strength rating than Primo. Primobolan is
actually a very weak anabolic steroid, weaker in fact, than
Testosterone itself. It possesses an anabolic rating of 88,
while Testosterone’s anabolic strength rating is 100 – this
demonstrates Primobolan’s fairly weak strength in terms of
anabolic capabilities. The same holds true for its androgenic
strength rating, which is approximately 44 – 57 in comparison
with Testosterone’s androgenic rating of 100. This weaker
androgenic strength rating is actually very favorable, but its
weak anabolic strength capability leaves it as a far less
desired anabolic steroid where the majority of individuals
considering its use often opt for Anavar instead. It is instead
utilized as primarily a compound in cutting cycles, whereby the
preservation of muscle mass is the goal instead of the addition
of new mass. Along this same line of logic, this anabolic is
almost never utilized in bulking cycles due to its lack in
anabolic strength.
Primobolan’s properties and details were first released and
published in 1960. Squibb released the injectable format of
Primobolan (Methenolone Enanthate) first in 1962 followed by the
release of the oral variant of Primo (Methenolone Acetate) into
the American market in the same year. It was at the time
marketed under the brand name Nibal Depot (for the injectable)
and Nibal for the oral variant dosed at 20mg per tablet. Very
shortly afterwards, the rights for manufacture of the compound
were sold in West Germany to Schering. Following this sale of
rights, Nibal was removed from the US market and instead,
Schering marketed the compound under the new trade name
Primobolan (for both variants). It then became the
quintessential anabolic steroid manufactured by Schering, who
then marketed the compound as an internationally exclusive drug,
and would never return to the American Market. An interesting
point to note is that even though Primobolan was never marketed
in the United States after Schering had bought the rights to it,
it is still listed as an FDA approved drug. This had enabled
American doctors to be able to import it on special order.
Within the medical field, Methenolone is utilized to treat
individuals suffering from conditions in which muscle wasting
and severe weight loss is a symptom. Other uses include: an
immunostimulant for individuals fighting infections, wasting
conditions, an adjunct to countering the effects of prolonged
corticosteroid therapy, and the treatment of osteoporosis as
well as sarcopenia (the loss of muscle as correlated with
aging). Primo, like Anavar, as proven to be so mild in its
negative effects that it has also been utilized in children as
well as infants in order to promote weight gain in premature
born infants without any indications of ill effects or toxicity.
One can easily see where the allure of this anabolic steroid
comes from within the athletic and bodybuilding community, as it
is a compound that exhibits weak androgenic effects with very
little to no side effects.
Like most anabolic steroids at the time, in the early 1990s it
was eventually pulled from all markets and Schering ceased
production as a result of the increasingly growing mass hysteria
surrounding anabolic steroids and the growing anti-steroid
sentiment in the media of the time. As a result, pharmaceutical
Primobolan manufactured by Schering is today only sold in a
small select number of countries across the world, such as Spain
Turkey, Japan, Paraguay, and Ecuador.
As far as the oral variant is concerned (Methenolone Acetate),
it too was pulled from the majority of markets and ceased
production as well. However, pharmaceutical grade oral Primo can
be located in Japan and South Africa. In general, pharmaceutical
grade oral Primobolan products are even more rare than the
injectable, and only small amounts of 5mg and 25mg tablets from
Schering may still be located on the market in extremely rare
and small amounts.
Chemical Characteristics of Primobolan
Primobolan is a Dihydrostestosterone (DHT) derivative, landing
it in the family of DHT-derivatives and analogues. Primo is a
modified form of DHT, where it contains a double-bond between
carbon atoms 1 and 2 in the Dihydrotestosterone structure. This
is known to assist in the stabilization of the 3-keto group
which in turn increases the anabolic strength of the hormone. A
1-methyl group is also added to the hormone, which is
responsible for allowing the hormone to resist hepatic (liver)
metabolism and breakdown.
The oral format of Primobolan holds an Acetate ester chemically
bonded to it, which is attached to the 17-beta-hydroxyl group on
the chemical structure. This allows the oral anabolic steroid to
be resistant to oxidation and hepatic breakdown through oral
administration. The oral form of Primobolan has demonstrated
effective oral bioavailability in studies as both in its Acetate
format as well as its un-esterified format. Esterification will
now be explained in more detail.
The injectable format (Methenolone Enanthate) in particular is
simply Methenolone with the Enanthate ester bound to the
Methenolone chemical structure. Specifically, ‘Enanthate’ is
Enanthoic acid (also known as carboxylic acid), but once bound
to Methenolone it is properly referred to in chemistry as an
ester bond (or ester linkage). Enanthoic acid is chemically
bonded to the 17-beta hydroxyl group on the Methenolone
structure. The addition of this ester augments the hormone’s
release rate and half-life to favor a longer window of release.
The primary reason for the augmentation of its half-life and
release rate is because once Methenolone Enanthate enters the
bloodstream, enzymes work to break the bond between the ester
and the hormone, which takes a varying amount of time. The end
result is that of the ester being removed from the hormone by
these enzymes, and the result after this is pure Methenolone
that is free to do its work in the body. This process of enzymes
removing the ester from the hormone to which it is attached is
what is responsible for the slower release rates. When the
Enanthate ester is attached to Methenolone, creating Methenolone
Enanthate, the half-life of Primobolan is now extended to 10
days, providing a slower release and activity of the hormone.
Properties of Primobolan
Primobolan being a DHT-derivative, it holds many of the same
properties of its parent hormone. For example its not aromatized
by the aromatase enzyme into Estrogen at any dose. Therefore,
any individual looking to utilize it should never experience any
Estrogen related side effects from using it alone. This means
that it completely avoids the potential for any of the following
side effects: water retention and bloating, elevated blood
pressure (as a result of water retention), possible fat
gain/retention, and gynecomastia. Without the puffy and soft
look that aromatizable anabolic steroids provide the physique,
Primobolan is regarded by the majority of bodybuilders and
athletes as a preferred ‘cutting’ compound considered very
useful for pre-contest cycles and fat loss and cutting phases.
Unfortunately, because of its poor anabolic strength rating
making it lower in strength than Testosterone, Primobolan is not
preferred by athletes or bodybuilders for bulking cycles, lean
mass cycles, or for any measurable strength gain. Primo is also
best combined with (stacked with) other anabolic steroids as
well, whether utilizing it for a cutting cycle or a bulking or
lean mass cycle. The use of Primobolan solitarily on its own is
regarded by many as a near useless practice, and along these
same lines, many anabolic steroid users claim that Primo is only
useful at very high doses, which may not be very practical
considering the high cost of this anabolic steroid. This dosing
information will be further expanded in the doses section of
this profile.
Primobolan Side Effects
The first thing to understand with Primobolan is that it is a
DHT-derivative, meaning it is a modified form of DHT
(Dihydrotestosterone). As such, it carries with it many similar
properties and characteristics, including the inability to
convert (aromatize) into Estrogen at any dose used[6]. This
should certainly be a comforting fact to most individuals who
are concerned about Estrogenic side effects, such as bloating,
gynecomastia, high blood pressure as a result of water
retention, etc.
Although the oral format of Primobolan is C-17 Alpha Alkylated
(also known as Methylation), which is a process that tends to
make oral compounds present a degree of harm to the liver,
Primobolan has never shown any measurable hepatotoxic effects to
the body[7]. Although oral Primo does not impose any measurable
negative effects on the liver, it still presents some small
amount of hepatotoxicity and this should still be understood,
especially when it comes to extended cycle lengths and/or very
high dosages. With that being said, one death of an anemic
patient who was prescribed oral Primobolan has been linked to
its use[8]. Once again, high doses and/or very long cycle
lengths of oral Primobolan may be a concern.
As much as Primobolan is touted by athletes and bodybuilders as
being a ‘mild’ anabolic steroid, it still exhibits suppression
of endogenous Testosterone production and HPTA function. In
fact, studies have confirmed that at even a very low dosage (30
– 45mg daily), test subjects experienced 15 – 65% suppression of
natural endogenous Testosterone production[9]. Being that those
dosages as far lower than what is required for performance
enhancement purposes, it is still heavily recommended to perform
a proper PCT (Post Cycle Therapy) following the discontinuation
of Primobolan.
Primobolan Cycles and Use
Primobolan cycles are commonly in the form of fat loss and/or
cutting cycles. It is almost never used as a bulking or
mass-gaining agent, and most of its use is in the form of a
pre-contest drug in the final weeks leading up to a competition
show or photo shoot. It is typically cycled with other compounds
that hold similar qualities, properties, and half-lives. Many
bodybuilders often stack Primobolan with Testosterone Propionate
(or Testosterone Enanthate) and use it for the first 8 weeks of
a cycle in order to assist in the retention of muscle mass
during periods of low caloric intake.
Other bodybuilders will perform oral Primobolan cycles stacked
with compounds such as Testosterone Propionate and Trenbolone
Acetate, as all of the compounds involved work synergistically
especially where half-lived are concerned. Some may opt to use
Primobolan (either the oral or injectable) with some form of
Testosterone and Winstrol (Stanozolol), typically the injectable
form if it is with the oral Primobolan. It is important to
remember not to utilized two different oral compounds within the
same cycle.
Oral Primobolan (Methenolone Acetate) should normally be run for
no longer than 8 weeks, and the injectable form (Methenolone
Enanthate) can be run in cycle lengths of 10 – 12 weeks (or
longer, depending on the individual’s goals and desires).
Primobolan Dosages and Administration
Primobolan dosage and administration depends heavily upon which
form is being used: oral or injectable. Medical prescription
Primobolan dosages outline 200mg as a first dosage, followed
with 100mg every week for the complete duration of therapy. The
medical condition being treated would determine what the actual
full Primobolan dosage is. The range can be anywhere from 100mg
every one or two weeks to 200mg every two to three weeks.
Medical guidelines for oral Primobolan dosages call for 100 –
150mg per day for no longer than 6 – 8 weeks of consistent use.
Where bodybuilding, athletics, and performance enhancement is
concerned, beginner Primobolan dosages for the injectable format
normally start at about 400mg per week. Intermediate Primobolan
dosages are usually in the range of 400 – 700mg per week, which
should be adequate enough, and advanced users may venture as
high as 800 – 1,000mg per week. Female Primobolan dosages in
terms of safety and minimal virilization are usually in the
range of 50 – 100mg per week. Injectable Primo tends to be used
far less frequently by females than the oral variant, which is
the preferred form.
Oral Primobolan dosages begin in the range of 50 – 100mg per day
for beginners, 100 – 150mg per day for intermediates, and 150 –
200mg for advanced users. Female oral Primobolan dosages are
usually recommended to be within the range of 50 – 70mg per day,
and should present little risk of virilization.
Oral Primo should be administered once per day with no
requirement to split up dosages throughout the day, as its
half-life is about 2 – 3 days. Injectable Primobolan exhibits a
half-life of 7 – 10 days due to the Enanthate ester, and should
be administered twice per week, with each injection spaced
evenly apart, in order to maintain stable and steady blood
plasma levels.
How to Buy Primobolan
Pharmaceutical grade Primobolan is long gone, as most
pharmaceutical grade Primo was pulled from the market long ago,
even internationally. Therefore, those looking about for how to
buy Primobolan, will generally only have luck with the
underground lab (UGL) manufactured products. With that being
said, a very, very small amount of human grade pharmaceutical
Primobolan exists on the market, and the oral format is rarer
than the injectable.
There are several different ways of how to buy Primobolan. The
most common and most popular these days tends to be internet
sources (either e-mail order sources, or websites). Secondary to
that are in-person ‘gym’ sources that deal with those looking to
buy Primobolan in-person, and generally go through cash
transactions. Prices can vary depending on the source type.
However, prices generally land in the following ranges. On the
expensive end, Injectable Primobolan can range from $200 – $230
per 10ml vial that is dosed at 100mg/ml for a UGL product, while
pharmaceutical product is as high as $20 – $25 for a single 1ml
glass ampule dosed at 100mg/ml. On the lower end, one can find
UGL grade injectable Primobolan for $90 – $130 per 10ml vial
dosed at 100mg/ml, and pharmaceutical product can be $12 – $18
for a single 1ml glass ampoule dosed at 100mg/ml.
Oral Primobolan on the expensive end can range from $2.50 –
$3.50 per tablet (50mg tablets) of UGL origin, and
pharmaceutical grade is even more expensive at $105 – $120 for a
lot/bottle of 50 tablets at 25mg per tablet. On the lower end,
oral Primobolan can be found for $1.50 – $2.50 per tablet
containing 10mg per tablet of UGL origin.
Primobolan Information:
Primobolan (Methenolone)
Chemical Name:
17beta-Hydroxy-1-methyl-5alpha-androst-1-en-3-one,
1-methyl-1(5-alpha)-androsten-3-one-17b-ol
Molecular Weight: 414.621 g/mol
Formula: C27H42O3
Original Manufacturer: Squibb
Half Life: 10 days (Enanthate), 2 – 3 days (oral)
Detection Time: 4 – 5 weeks
Anabolic Rating: 88
Androgenic Rating: 44 – 57
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