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STUDY ZINIC OPEN WOUNDS AND FOOT ULCER AND DIABETIC WOUNDS
By: Road2HardCoreIron Date: November 26, 2023, 9:21 am
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HTML https://pubmed.ncbi.nlm.nih.gov/28395131/
doi: 10.1111/wrr.12537. Epub 2017 May 9.
The effects of zinc supplementation on wound healing and
metabolic status in patients with diabetic foot ulcer: A
randomized, double-blind, placebo-controlled trial
Mansooreh Momen-Heravi 1 2, Elham Barahimi 1, Reza Razzaghi 1,
Fereshteh Bahmani 3, Hamid Reza Gilasi 4, Zatollah Asemi 3
Affiliations expand
PMID: 28395131 DOI: 10.1111/wrr.12537
Abstract
This study was performed to determine the effects of zinc
supplementation on wound healing and metabolic status in
patients with diabetic foot ulcer. The current randomized,
double-blind, placebo-controlled trial was conducted among 60
patients (aged 40-85 years old) with grade 3 diabetic foot
ulcer. Participants were randomly divided into two groups (30
participants in each group) to take either 220 mg zinc sulfate
supplements containing 50 mg elemental zinc or placebo daily for
12 weeks. After the 12-week intervention, compared with the
placebo, zinc supplementation was associated with significant
reductions in ulcer length (-1.5 ± 0.7 vs. -0.9 ± 1.2 cm, p =
0.02) and width (-1.4 ± 0.8 vs. -0.8 ± 1.0 cm, p = 0.02). In
addition, changes in fasting plasma glucose (-40.5 ± 71.0 vs.
-3.9 ± 48.5 mg/dl, p = 0.02), serum insulin concentration (-8.0
± 15.4 vs. +1.1 ± 10.3 µIU/ml, p = 0.009), homeostasis model of
assessment-estimated insulin resistance (-3.9 ± 7.1 vs. +0.8 ±
5.9, p = 0.007), the quantitative insulin sensitivity check
index (+0.01 ± 0.03 vs. -0.002 ± 0.02, p = 0.04) and HbA1c (-0.5
± 0.8 vs. -0.1 ± 0.5%, p = 0.01) in the supplemented group were
significantly different from the changes in these indicators in
the placebo group. Additionally, significant increases in serum
HDL-cholesterol (+4.1 ± 4.3 vs. +1.1 ± 5.1 mg/dl, p = 0.01),
plasma total antioxidant capacity (+91.7 ± 213.9 vs. -111.9 ±
188.7 mmol/L, p < 0.01) and total glutathione (+68.1 ± 140.8 vs.
-35.0 ± 136.1 µmol/L, p = 0.006), and significant decreases in
high sensitivity C-reactive protein (-20.4 ± 24.6 vs. -6.8 ±
21.3 µg/ml, p = 0.02) and plasma malondialdehyde concentrations
(-0.6 ± 0.9 vs. -0.2 ± 0.7 µmol/L, p = 0.03) were seen following
supplementation with zinc compared with the placebo. Zinc
supplementation for 12 weeks among diabetic foot ulcer patients
had beneficial effects on parameters of ulcer size and metabolic
profiles.
© 2017 by the Wound Healing Society.
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Publication types
Randomized Controlled Trial
MeSH terms
Adult
Aged
Aged, 80 and over
Anti-Inflammatory Agents / pharmacology
Anti-Inflammatory Agents / therapeutic use*
Blood Glucose / metabolism
C-Reactive Protein / metabolism
Diabetic Foot / blood
Diabetic Foot / complications
Diabetic Foot / drug therapy*
Diabetic Foot / metabolism*
Dietary Supplements
Double-Blind Method
Female
Glycated Hemoglobin / metabolism
Humans
Insulin Resistance
Iran
Male
Malondialdehyde / blood
Middle Aged
Severity of Illness Index
Treatment Outcome
Wound Healing / drug effects*
Wound Healing / physiology
Zinc / pharmacology
Zinc / therapeutic use*
Substances
Anti-Inflammatory Agents
Blood Glucose
Glycated Hemoglobin A
hemoglobin A1c protein, human
Malondialdehyde
C-Reactive Protein
Zinc
Associated data
IRCT/IRCT201506215623N46
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