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Victoza
By: Road2HardCoreIron Date: January 12, 2023, 4:55 pm
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What’s Victoza?
Victoza is an injectable medication that’s FDA approved to lower
blood sugar in people with Type 2 diabetes who are ages 10 and
up. It’s also approved to lower the risk of cardiovascular
events (like heart attack, stroke) in people with diabetes and
cardiovascular disease (like coronary artery disease, peripheral
artery disease).
Victoza is given once a day. It comes as an injector pen and is
injected subcutaneously (underneath the skin). Each pen contains
18 mg of liraglutide.
It can be given as a dose of 0.6 mg, 1.2 mg, or 1.8 mg. The
starting dose of Victoza is usually 0.6 mg, but this isn’t
considered an effective dose to treat diabetes. After a week,
the dose will likely be increased to 1.2 mg. After another week,
your healthcare provider may raise the dose to 1.8 mg.
What’s the difference between Victoza and diabetes pills?
Victoza is an injection given underneath the skin. But there are
other diabetes medications that can be taken orally. Like
Victoza and Saxenda, some of these diabetes pills may help
people lose weight. But others may lead to weight gain.
Is Victoza a type of insulin?
No. Victoza mimics a hormone in the body called glucagon-like
peptide-1 (GLP-1). One of Victoza’s actions is to stimulate the
body to produce more insulin after you eat. Insulin is a hormone
that helps control your blood sugar. But Victoza itself does not
contain insulin.
Is Victoza FDA approved for weight loss?
Victoza isn’t approved for weight loss.
But a different liraglutide product, Saxenda, was FDA approved
in 2020 to help certain groups of people lose weight. This
includes:
Adults with obesity
Adults with overweight with at least one weight-related
condition (like high blood pressure, high cholesterol, or Type 2
diabetes)
Kids, ages 12 and up, who weigh at least 60 kg (132 lb)
Saxenda is meant to be used in combination with diet and
exercise.
How does Victoza work for weight loss and diabetes?
Liraglutide is a GLP-1 agonist. It works by mimicking the
effects of GLP-1, a type of incretin hormone.
Your gut makes incretin hormones like GLP-1 after you eat. GLP-1
sends signals to your pancreas to release insulin. By mimicking
GLP-1, liraglutide increases the amount of insulin that’s
released. This helps keep your blood sugar under control.
GLP-1 also increases the amount of time it takes for food to
travel through your digestive tract. And it blocks a hormone
(glucagon) that causes your liver to release sugar. These
actions help lower your appetite, and can lead to weight loss.
How effective is Victoza for weight loss
Victoza has been shown to help people who have diabetes lose
weight. This is important because weight loss can improve Type 2
diabetes and help you avoid other complications, like heart
problems.
But Victoza can also help people who don’t have diabetes lose
weight. Let’s take a look.
Victoza for weight loss in people who have diabetes
One study of over 700 people with Type 2 diabetes found that
Victoza 1.8 mg and 1.2 mg doses led to weight loss. People using
Victoza 1.8 mg lost about 2.5 kg (5.5 lbs) and those using
Victoza 1.2 mg lost about 2.1 kg (4.6 lbs).
Another study compared liraglutide 3 mg and liraglutide 1.8 mg
to placebo (a pill with nothing in it). The researchers found
that both doses helped people who had Type 2 diabetes lose more
weight than placebo did. But liraglutide 3 mg caused more weight
loss than the 1.8 mg dose. People taking liraglutide 3 mg lost
an average of 6.4 kg (14 lbs). People taking liraglutide 1.8 mg
lost about 5 kg (11 lbs). Liraglutide 3 mg helped a significant
amount of people lose more than 10% of their initial body
weight.
Victoza for weight loss in people who don’t have diabetes
A study comparing four doses of liraglutide (1.2 mg, 1.8 mg. 2.4
mg, and 3 mg) found that each dose led to more weight loss than
placebo. But only liraglutide 3 mg led to greater than a 5%
reduction in body weight in significantly more people than
placebo. The study also compared liraglutide to another weight
loss medication called orlistat (Alli). Only liraglutide 2.4 mg
and liraglutide 3 mg cause significantly more weight loss than
orlistat.
Most studies of liraglutide in people without diabetes focus on
the 3 mg dose (the dose of Saxenda). Victoza isn’t FDA approved
at this dose. And remember, Victoza isn’t specifically FDA
approved for weight loss. But Saxenda is.
In a study of over 3,500 people, liraglutide 3 mg led to an
average weight loss of 8.4 kg (18.5 lbs). This was much higher
than the average weight loss of 2.8 kg (6 lbs) with placebo.
It’s important to note that people in this study were encouraged
to exercise regularly and eat a well-balanced diet during the
study.
What are the side effects of Victoza?
As with any medication, Victoza can cause unwanted side effects.
Some of these side effects may improve over time as your body
gets used to the medication.
Common side effects include:
Nausea and vomiting
Diarrhea or constipation
Headache
Lowered appetite
Upset stomach
Injection site reactions
In rare cases, Victoza can lead to serious side effects that
require immediate medical attention. One serious side effect is
the risk of causing thyroid C-cell tumors. While these types of
tumors have only been seen in animal studies, you should still
avoid Victoza (and Saxenda) if you have a personal or family
history of thyroid cancer. Victoza and Saxenda have a boxed
warning for this risk, which is the FDA’s strictest warning for
a medication.
Other serious side effects include:
Hypoglycemia (low blood sugar)
Pancreatitis (inflammation of the pancreas)
Gallbladder problems (including gallstones and inflammation)
Kidney problems
Serious allergic reactions (including anaphylaxis)
The bottom line
Victoza is a GLP-1 agonist that's FDA approved to treat Type 2
diabetes. It’s an injection that’s given underneath the skin
daily. In studies, it’s been shown to help with weight loss in
people with and without diabetes. But it’s not specifically FDA
approved for this reason.
Another medication (Saxenda) with the same active ingredient as
Victoza (liraglutide) is FDA approved for weight loss. Saxenda
is approved at a higher dose (3 mg) than Victoza (1.2 and 1.8
mg). The 3 mg dose has been shown to be more effective than
lower doses at helping people lose weight.
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