DIR Return Create A Forum - Home
       ---------------------------------------------------------
       Road2HardCoreIron
  HTML https://road2hardcoreiron.createaforum.com
       ---------------------------------------------------------
       *****************************************************
   DIR Return to: National Library of Medicine
       *****************************************************
       #Post#: 1549--------------------------------------------------
       National Library of Medicine Report on Synthol Incident
       By: Road2HardCoreIron Date: November 15, 2022, 4:05 pm
       ---------------------------------------------------------
       eCollection 2021 Sep.
       Synthol systemic complications: Hypercalcemia and pulmonary
       granulomatosis. A case report
       Mersad Alimoradi 1, Ahmad Chahal 2, Elie El-Rassi 3, Karim Daher
       3, Gazy Sakr 4
       Affiliations expand
       PMID: 34522373 PMCID: PMC8426527 DOI: 10.1016/j.amsu.2021.102771
       Free PMC article
       Abstract
       Introduction: Synthol injection for body contouring has been
       used by bodybuilders for some time. We report two extremely rare
       systemic complications; pulmonary granulomatosis and
       hypercalcemia, in a woman who has received Synthol injections
       for buttocks augmentation.
       Presentation of case: The case discussed in this report is of a
       36-year-old lady who presented for severe hypercalcemia and
       nephrocalcinosis. Subsequent workup revealed granulomas in the
       buttocks and in the lungs. Upon questioning, it was discovered
       that she had received Synthol injection for buttocks
       augmentation a few months earlier. Labs were consistent with
       calcitriol mediated hypercalcemia, a phenomenon observed in
       granulomatous diseases. A diagnosis of foreign body
       granulomatosis with pulmonary migration and secondary
       hypercalcemia was made. The patient was started on prednisone
       and showed an initial positive response.
       Discussion: Reported complications of Synthol include pain,
       muscle deformity, and ulceration at the injection site.
       Hypercalcemia secondary to foreign body granulomatosis after
       Synthol injection has been reported only once previously, and
       here we report a second case. The hypercalcemia is thought to be
       calcitriol mediated, where overexpression of CYP27B1 in the
       macrophages forming the granulomas leads to pathological
       extrarenal calcitriol production. Pulmonary granulomatosis,
       theorized to be secondary to hematologic migration of the
       injected material, has never been reported previously with
       Synthol use.
       Conclusion: Synthol injection for body contouring may be a cause
       of extensive local and pulmonary foreign body granulomatosis
       leading to calcitriol mediated hypercalcemia. History of
       cosmetic injections should not be disregarded during history
       taking.
       Keywords: Body contouring; CT, computed tomography; ESWL,
       extracorporeal shock wave lithotripsy; Fillers complication;
       Foreign body granulomatosis; Hypercalcemia; KUB, Kidney ureter
       bladder; Lung granuloma; Nephrocalcinosis; Nephrolithiasis; PET,
       positron emission tomography; PMMA, polymethylmethacrylate; PTH,
       parathyroid hormone; Synthol.
       © 2021 The Author(s).
       Conflict of interest statement
       The authors report no conflict of interest with any parties in
       regards to this research article.
       *****************************************************