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#Post#: 1483--------------------------------------------------
L-Carnitine Fat Loss Study
By: Road2HardCoreIron Date: November 12, 2022, 11:52 am
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Effects of l-carnitine supplementation on weight loss and body
composition: A systematic review and meta-analysis of 37
randomized controlled clinical trials with dose-response
analysis
Nasir Talenezhad et al. Clin Nutr ESPEN. 2020 Jun.
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Abstract
Background and aim: Clinical evidence which investigated the
effects of l-carnitine, a vitamin-like substance, on weight loss
had led to inconsistent results. This study therefore aimed to
examine the effect of l-carnitine supplementation on body weight
and composition by including the maximum number of randomized
controlled trials (RCTs) and to conduct a dose-response
analysis, for the first time.
Methods and results: Online databases were searched up to
January 2019. In total, 37 RCTs (with 2292 participants) were
eligible. Meta-analysis showed that l-carnitine supplementation
significantly decreased body weight [Weighted mean difference
(WMD) = -1.21 kg, 95% confidence interval (CI): -1.73, -0.68; P
< 0.001], body mass index (BMI) (WMD = -0.24 kg/m2, 95% CI:
-0.37, -0.10; P = 0.001), and fat mass (WMD = -2.08 kg, 95% CI:
-3.44, -0.72; P = 0.003). No significant effect was seen for
waist circumference (WC) and body fat percent. The meta-analysis
of high-quality RCTs only confirmed the effect on body weight. A
non-linear dose-response association was seen between
l-carnitine supplementation and body weight reduction (P <
0.001) suggesting that ingestion of 2000 mg l-carnitine per day
provides the maximum effect in adults. This association was not
seen for BMI, WC and body fat percent.
Conclusions: l-carnitine supplementation provides a modest
reducing effect on body weight, BMI and fat mass, especially
among adults with overweight/obesity.
Keywords: Body composition; Body mass index; Body weight;
L-carnitine; Meta-analysis; Systematic review.
Copyright © 2020 European Society for Clinical Nutrition and
Metabolism. Published by Elsevier Ltd. All rights reserved.
Conflict of interest statement
Declaration of Competing Interest The authors declare that they
have no conflict of interest.
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