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       #Post#: 1444--------------------------------------------------
       Growth Hormone and Insulin Combine to Improve Whole-body and Ske
       letal Muscle Protein
       By: Road2HardCoreIron Date: November 9, 2022, 6:23 pm
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       Growth hormone and insulin combine to improve whole-body and
       skeletal muscle protein kinetics
       R F Wolf 1, M J Heslin, E Newman, D B Pearlstone, A Gonenne, M F
       Brennan
       Affiliations expand
       PMID: 1641767
       Abstract
       Background: A cooperative effect of exogenous insulin and
       recombinant human growth hormone (r-hGH) with respect to
       whole-body and skeletal muscle protein metabolism has not been
       demonstrated previously. This study examined the effect of r-hGH
       and insulin administration during euglycemic clamping and
       concurrent amino acid supplementation.
       Methods: Twenty-three normal volunteers in the postabsorptive
       state were either treated with r-hGH for 3 consecutive days
       before a metabolic study (GH group; n = 10) or not treated (CTRL
       group; n = 13). The r-hGH dose was 0.2 mg/kg/day (n = 5) or 0.1
       mg/kg/day (n = 5). All subjects then received an infusion of
       14C-labeled leucine and tritiated phenylalanine, followed by
       measurement of baseline protein kinetics (GH and CTRL).
       Subsequently a euglycemic insulin infusion (1 mU/kg/min) with
       concurrent amino acid infusion was administered, and protein
       kinetic measurements were repeated at steady state.
       Results: GH and insulin separately produced an increase in
       whole-body and skeletal muscle protein net balance. GH plus
       insulin was associated with a higher net balance of protein than
       was insulin alone.
       Conclusions: r-hGH and insulin in the presence of amino acids
       and glucose combine to improve whole-body and skeletal muscle
       protein kinetics.
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