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#Post#: 3734--------------------------------------------------
Psoriasis and other Autoimmune Disorders
By: AGelbert Date: September 9, 2015, 2:01 pm
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Vitae Pharmaceuticals Announces Positive Top-Line Results From
Initial Phase 1 Study of First-in-Class RORyt Inhibitor
VTP-43742 in Autoimmune Disorders
• Single ascending doses of VTP-43742 safe and generally
well-tolerated, demonstrated once-daily pharmacokinetics
• Robust ex vivo biomarker response, suppressing
pro-inflammatory IL-17A by more than 90 percent
FORT WASHINGTON, Pa., Sept. 8, 2015 (GLOBE NEWSWIRE) -- Vitae
Pharmaceuticals, Inc. (NASDAQ:VTAE), a clinical-stage
biotechnology company, today announced positive top-line results
from its Phase 1 single ascending dose clinical study of
VTP-43742 in autoimmune disorders. VTP-43742 is Vitae's
first-in-class, wholly owned RORγt inhibitor being
developed for the treatment of a range of autoimmune disorders,
potentially including psoriasis, psoriatic arthritis, rheumatoid
arthritis, multiple sclerosis and irritable bowel disease (IBD),
as well as numerous orphan diseases.
HTML http://ir.vitaepharma.com/phoenix.zhtml?c=219654&p=irol-newsArticle&ID=2086185
VTAE stock jumps over 70%! :o
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#Post#: 12356--------------------------------------------------
Itches: Causes and Consequences
By: AGelbert Date: May 11, 2019, 1:43 pm
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width=640]
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[center]
HTML https://nationaleczema.org/why-do-we-itch/[/center]
[center]Why Do Itches Seem to Get Worse When You Scratch Them?
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width=50]
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It’s a vicious cycle. You’ve got this itch that just has to be
scratched. Then you scratch so hard that it hurts. That’s where
the brain comes in, releasing serotonin to calm the pain you’ve
created. The unfortunate side effect of all that, scientists
have discovered, is that the release of serotonin also activates
brain cells called GRPR neurons, which trigger a renewed round
of that uncontrollable urge to itch. :( Researchers at the
Washington University School of Medicine in St Louis came to
this conclusion in 2014 while studying genetically-modified mice
that did not produce serotonin.
Itches, scratches, and serotonin:
🕯️ Normal mice injected with a chemical will
scratch like crazy. The researchers found that without the
serotonin response, the mice had no urge to scratch, thus
proving serotonin’s role in the process. 👀
🕯️ Could blocking serotonin in humans stop the
itch? Maybe, but then they’d have no natural way to control
pain. However, there may be a way to stop serotonin from
activating the nerve cells in the spinal cord that instigate
itch. 🤔
🕯️ The researchers 👨‍🔬 did
identify the nerve receptor known as 5-HT1A as the key to
unleashing those itch-specific GRPR neurons in the spinal cord.
Their research appeared in the scientific journal Neuron.
HTML https://www.wisegeek.com/why-do-itches-seem-to-get-worse-when-you-scratch-them.htm
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