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       #Post#: 38--------------------------------------------------
       serology, Yunnan, 2015
       By: gsgs Date: February 2, 2020, 12:57 am
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  HTML https://link.springer.com/content/pdf/10.1007/s12250-018-0012-7.pdf
       (Nov.2017)  Serological Evidence of Bat SARS-Related Coronavirus
       Infection
       in Humans, China
       [my selection from that paper:]
       to date, no evidence of direct transmission of SARSr-CoVs from
       bats
       to people has been reported.
       In October 2015, we collected serum samples from 218 residents
       in four villages
       in Jinning County, Yunnan  located 1.1–6.0 km from two caves
       (Yanzi and Shitou).
       85.3% farmers and 8.7% students. Most (81.2%) kept or owned
       livestock or pets,
       and the majority (97.2%) had a history of exposure to or contact
       with livestock
       or wild animals. Importantly, 20 (9.1%) participants witnessed
       bats flying close
       to their houses,
       As a control, we also collected 240 serum samples from random
       blood donors
       in 2015 in Wuhan,  where inhabitants have a much lower
       likelihood of contact with bats due to its urban setting.
       Our study provides the first serological evidence of
       likely human infection by bat SARSr-CoVs or, potentially,
       related viruses. The lack of prior exposure to SARS
       patients by the people surveyed, their lack of prior travel to
       areas heavily affected by SARS during the outbreak, and
       the rapid decline of detectable antibodies to SARS-CoV in
       recovered patients within 2–3 years after infection strongly
       suggests that positive serology obtained in this study is not
       due to prior infection with SARS-CoV (Wu et al. 2007).
       The 2.7% seropositivity for the high risk group of residents
       living in close proximity to bat colonies suggests that
       spillover is a relatively rare event, however this depends on
       how long antibodies persist in people, since other indi-
       viduals may have been exposed and antibodies waned.
       From our previous studies of bat SARSr-CoVs in
       the two caves near these villages, we have found geneti-
       cally highly diverse bat SARSr-CoVs and evidence of
       frequent coinfection of two or more different SARSr-CoVs
       in the same bat (Ge et al. 2013).
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