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#Post#: 12--------------------------------------------------
takes over a year (Jan.2020)
By: gsgs Date: January 30, 2020, 1:12 am
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January 27th, 2020, 11:50 AM
Fauci,NIH : 1 year
Fauci said it would take a few months until the first phase of
clinical trials begins and
more than a year until a vaccine is available
Tregoning, Imperial College at Bloomberg : 5-6 Months
University of Queensland : 16 weeks , 6 months
The team hopes to develop a vaccine over the next six months,
which may be used to help
contain this outbreak,” he said. “The vaccine would be
distributed to first responders,
helping to contain the virus from spreading around the world.”
(Paul Young)
Dr. Tal Zaks, Moderna’s chief medical officer, committed to
getting that done
on CEPI’s 16-week timeline. And the company will be able to
manufacture the
eventual vaccine in a matter of a few months, Zaks said. That
should cover
clinical trials, he said, but if the vaccine ends up working —
and the 2019-nCoV
outbreak drags on — the company would have to rely on someone
else to
churn out the massive number of doses required to halt the
virus.
David Weiner , Inovio : "much faster".
Gregory Glenn from Novavax says that his firm is working on
developing a
vaccine for the China coronavirus, and work on that could take
two to three months.
CEPI : In 16 Wochen sollen die ersten Impfstoffe gegen das
neuartige Coronavirus
getestet werden Eine Erfolgsgarantie gebe es allerdings nicht.
Laut Experten dürfte es aber mindestens ein Jahr dauern, bis ein
fertiger Impfstoff
zur Verfügung steht.
-----------------------------------------
I speculate they could somehow reduce the testing phase, if time
urges,
That makes it somehow risky, but hey, the pandemic is the bigger
risk.
I can't find any statements on this, though. But maybe they
mustn't talk
about this ... it's all commercial,legal.government - they can't
just speak freely.
Jan.29
China coronavirus: Hong Kong researchers have already developed
vaccine but need
time to test it, expert reveals
Johnson & Johnson JNJ, +0.70% now plans to initiate development
of a vaccine
candidate for 2019-nCoV and is also providing its antiviral HIV
treatment Prezcobix in
China for investigational purposes.
Becton Dickinson and Co. BDX, -0.02%, the diagnostics company,
is sending
instruments used in diagnostic testing to China
TAWA — Canada’s chief public health officer says it will likely
take at least a year
before a vaccine is developed to protect people against the new
coronavirus t
Dr. Theresa Tam
Jan.29 , Novartis CEO
it will take over a year until there is a vaccine
[in Europe or worldwide ? also in China with maybe reduced
trial-regulations ? ]
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Vaxart, Inc., a clinical-stage biotechnology company developing
oral recombinant vaccines
administered by tablet rather than by injection, announced on
Jan.31 that it has initiated
a program to develop a coronavirus vaccine candidate based on
its proprietary oral
vaccine platform, VAAST.
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Feb-05 Sweden: Karolinska joins global hunt for coronavirus
vaccine.
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Der britische Epidemiologe Jeremy Farrar geht davon aus, dass
ein Impfstoff gegen das neuartige Coronavirus 2019-nCoV zu spät
kommen wird, um die drohende globale Ausbreitung der Seuche zu
verhindern. „Realistischerweise wird ein Impfstoff frühestens
zum Jahresende fertig oder in einem Jahr – und das wäre schon in
Rekordzeit“, sagte Farrar dem „Spiegel“. Wenn man Pech habe,
werde es „niemals gelingen“.
Der Direktor des Wellcome Trust
„Es könnte sogar sein, dass das neuartige Coronavirus anders als
Influenzaviren nicht nur hauptsächlich saisonal auftritt,
sondern das ganze Jahr kursiert“, so der Mediziner weiter. Er
bezweifelt, dass die Bewohner westlicher Metropolen wie München
oder Paris im Falle einer Pandemie eine wochenlange Abriegelung
ihrer Städte wie in China hinnehmen würden.
Wenn alles nach Plan läuft, könnte es bis zum Jahresende ein
Serum geben. Ist ein Impfstoff gefunden, muss er noch einen
langen Weg bis zur Zulassung gehen.
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#Post#: 102--------------------------------------------------
Re: takes over a year (Jan.2020)
By: gsgs Date: February 13, 2020, 2:35 am
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Researchers in China and the US are developing a vaccine for the
new Coronavirus.
If all goes well, they may run the first tests in three months.
A vaccine would be
available mid-year — at the very earliest.
HTML https://www.dw.com/en/coronavirus-vaccine-a-race-against-time/a-52174737
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--
Even if it all goes well, the earliest a vaccine against nCoV
could be introduced would
be the summer of 2020.
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Another potential approach against the coronavirus nCoV is with
monoclonal antibodies,
which can activate specific immunological reactions in the body.
Herbert Virgin at Vir Biotechnology in Illinois, USA, says his
company has developed
antibodies which have shown themselves to be effective against
SARS and MERS in
laboratory tests. Some were reportedly able to neutralize
coronaviruses. "It's possible that
they could also treat the Wuhan virus," says Virgin.
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-
Prof. Mark Harris, a virologist at the School for Molecular and
Cell Biology at the
University of Leeds in the UK, estimates the mortality rate of
nCoV to be at 0.1 percent.
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A spokesman for the Institutes (NIH) said that it could be a few
months before the first
clinical trials of the vaccine get underway – and a year
or more before it’s available.
----------------------------------------
Meanwhile, Baylor College of Medicine in Houston is also
reported to be working on a vaccine.
----------------------------------------
so they are going to test it on animals who so far have not been
found to catch the virus
so whats that going to prove apart from if it does not kill an
animal it MAY be ok for
humans why not just test it on a confirmed subject and bypass
animal crue..
--------------------------------------
Feb.12
The first vaccine targeting the new coronavirus could be 18
months away, and the outbreak
could end up creating a global threat potentially worse than
terrorism, the WHO has warned.
--------------------------------------------------
At least a dozen research teams globally have already made
headway in vaccine research
against the new coronavirus.
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Dr. Anthony Fauci, director of the NIAID, said they are on track
to test their vaccine by April.
“Whenever you’re dealing with a vaccine,
there’s always a potential for glitches,”
“Right now, all those glitches, they’ve been
overcome.”
Phase one of human testing will still take at least three months
to complete, he said.
Then a decision has to be made about whether the vaccine will
advance to a phase two trial.
“The risk is the companies now have to invest a lot of
money,” Fauci said. “You would
have to do a trial of several hundred to several thousand people
to see if it works —
that usually takes anywhere from several months to a couple of
years.”
Even with expedited approval, phase two of the new coronavirus
vaccine would require
a time investment of at least a year, he said.
------------------------------------------------
The 'holy grail' universal vaccine
Another competitive advantage the team enjoys is Hogue’s
prior experience working
on a SARS vaccine, which should speed up their work on the new
coronavirus vaccine,
since the new virus is about 80% similar to SARS at the genetic
level.
In hindsight, Hogue wishes she had continued to work on her SARS
vaccine.
"At the time we were pursuing this, we didn't have all that
background and understanding
that there were a lot of these SARS-like viruses that could
infect humans,” she said.
-------------------------------------------------------
An expert in infectious diseases on Monday said it was possible
there could be a vaccine
against the new virus originating in China "at the very
earliest" by September.
Chair of Infectious Disease Epidemiology at Imperial College
London, Professor Azra Ghani,
added "it's more likely to be towards the end of the year".
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In Kooperation mit dem Forscherteam um Sutter arbeitet auch eine
Gruppe
um den Virologen Stephan Becker, Direktor des Instituts für
Virologie an der
Philipps Universität Marburg und Koordinator des
Forschungsbereichs
Neu auftretende Infektionskrankheiten am Deutschen Zentrum für
Infektionsforschung (DZIF), an einem Impfstoffkandidaten.
Wenn der politische oder medizinische Druck hoch genug sei, dann
würden
die Zulassungsverfahren beschleunigt, zeigten seine Erfahrungen.
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#Post#: 140--------------------------------------------------
Re: takes over a year (Jan.2020)
By: gsgs Date: March 2, 2020, 9:58 am
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@HelenBranswell
This feels very optimistic for vaccine for the masses.
Some people *may* get vaccinated in 18 months. But it won't be
most of us.
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@florian_krammer
Vaccines against SARS-CoV-2 will be very important. But don't
get fooled by press releases.
To get them will take time.
Merck and J&J did their phase 1-2-3 more or less in parallel.
Will the FDA / EMA allow such
an approach for covid-19 vaccine?. I would hope so.
@nataliexdean
If Phase 3 trials are successful, there is also a precedent for
immediately providing the vaccine
under an emergency use authorization (pre-licensure) as long as
recipients provide informed
consent. This has been done in the DRC for Ebola.
Woman shrugging
@fodaazul
6 to 18 months? There’s 4 to 16 months left only
#Post#: 141--------------------------------------------------
Re: takes over a year (Jan.2020)
By: gsgs Date: March 3, 2020, 2:25 am
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HTML https://www.republicworld.com/world-news/rest-of-the-world-news/expert-virus-vaccine-possible-by-sep-at-earliest.html
Azra Chani
Azra Ghani,
Weiner, Imp.Coll.London
“We were able to go from no vaccine to a vaccine tested in the
clinic in about 18 months — 15 to 18 months,”
“And we were able to design and develop and move into the
clinic in 11 months [MERS].”
Keith Chappell at the University of Queensland in Brisbane,
Australia, thinks he can do even better
HTML https://cbdnewsupdate.com/timetable-for-a-vaccine-against-the-new-coronavirus-maybe-this-fall/
Even in the rosiest of scenarios, Hatchett says, once the
vaccine is in hand, it still needs to get to the people who need
it, and that takes time — at least weeks to months, depending on
the urgency.
“We are making very aggressive efforts in the hopes of having a
vaccine available — some form of vaccine available, potentially,
as early as this fall,” Hatchett says.
#Post#: 142--------------------------------------------------
Re: takes over a year (Jan.2020)
By: gsgs Date: March 3, 2020, 2:59 am
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Fauci repeating on Mar02 : Fauci :
“A year to a year and a half,” referring to the amount of time
it will likely take to
deploy an effective vaccine to large populations.
[ with their approach ? with current US-vaccine-laws ? ]
==================================================
More than 20 new crown pneumonia vaccines are being developed
worldwide, and these
have made new progress
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American pharmaceutical company Inovio Pharmaceuticals said on
March 3 that the company is
accelerating the development of a vaccine schedule for the
treatment of new coronary pneumonia.
Inovio is currently expected to provide 1 million doses of
vaccines using existing resources
by the end of the year.
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---------------------------------
It is reported that the laboratory team led by Professor Robin
Shattock, head of mucosal
infections and immunology at Imperial College London, focuses on
the development of a
coronavirus vaccine. They developed the vaccine within 14 days
and last week Began
to enter the animal test stage, and it is possible to conduct
human trials within 5 months.
If progress is smooth, human clinical trials will be conducted
this summer. (Finished by
Health Times reporter Qiao Jingfang)
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! Professor Ning Yi from the School of Public Health of Peking
University said in an interview
with a Health Times reporter that the fastest time from vaccine
development to market is 6 months,
and the probability of successful vaccine development before
August is "zero".
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US pharmaceutical company Moderna has sent vaccine samples to
U.S. government researchers
this Monday. It is expected to be tested on 45 healthy
volunteers by the end of April. The first
phase will take at least three months. Then entering the second
phase will require hundreds of
volunteers to test, and the rocket speed will also take 6-8
months. That is to say, the fastest time
is one to one and a half years.
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#Post#: 243--------------------------------------------------
Re: takes over a year (Jan.2020)
By: gsgs Date: June 17, 2020, 6:26 am
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2020/06/17
Das Tübinger Biotechunternehmen CureVac geht davon aus, dass es
bis Mitte kommenden Jahres
einen Corona-Impfstoff geben könnte.
#Post#: 245--------------------------------------------------
Re: takes over a year (Jan.2020)
By: gsgs Date: June 24, 2020, 6:12 am
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22.05.2020 · “This contract with AstraZeneca is a major
milestone in Operation Warp
Speed’s work toward a safe, effective, widely available vaccine
by 2021,” U.S. Health
Secretary Alex Azar said.
Operation Warp Speed Aims to Deliver 300M Vaccine Doses by
January.
A potential coronavirus vaccine developed by French drugmaker
Sanofi and Britain's
GlaxoSmithKline is expected to be approved by the first half of
2021.
Sanofi said it had capacity to produce up to 1 billion doses a
year
Shionogi and the NIID aim to put the vaccine on the market in
fall 2021.
Pfizer/BioNTech 2M per dec31, 200M in 2021
AS, May, total capacity sourced for one billion doses through
2020 and into 2021;
AstraZeneca (ticker: AZN) has arranged for enough capacity to
supply one billion doses of the vaccine in 2020 and 2021
May 21 (Reuters) - AstraZeneca expects to be able to deliver a
billion doses of a possible
COVID-19 vaccine this year and next
AstraZeneca says it has secured capacity to produce 2 billion
doses
84-90% of vaccine candidates fail (have "attrition") in Phase
III clinical trials[4][54]
Walter Ricciardi,WHO : there is quite a strong probability that
the vaccine will work
Sanofi would be able to supply up to 360 million doses of its
mRNA vaccine annually
In April, Sanofi said it had manufacturing capacity for 600
million doses for its recombinant
vaccine, with the ambition to double production by mid-2021.
Sanofi said it had capacity to produce up to 1 billion doses a
year
23.06.2020 · Sanofi said it had capacity to produce up to 1
billion doses a year of its recombinant
vaccine, and that it would be able to supply up to 360 million
doses of its mRNA vaccine annually.
"We believe the probability of success is high enough that we
are willing to support the
manufacturing at-risk," Dr. Hatchett said.
AstraZeneca said it reached a second agreement with the Serum
Institute of India to provide
one billion doses for low and middle-income countries, including
400 million by the end of this year.
Last month, AstraZeneca agreed to provide 100 million doses to
the U.K., with an initial
supply of 30 million doses per September.
Initial supplies of any successful vaccine are expected to be
limited. Some drugmakers have
sought to set up manufacturing capacity in multiple countries,
in case individual countries
impose export bans on any successful vaccines produced within
their borders.
June 04, 2020
Jun 16 , HHS says vaccine likely by January
when a safe and effective vaccine will be developed and
distributed, and on Tuesday, the
Department of Health and Human Services said that January 2021
is a likely timeframe for
when that might happen.
The projection is based on the current efforts of HHS' Operation
Warp Speed, an initiative that
aims to deliver 300 million doses
stay-at-home and other social-distancing orders have cost the
country an estimated $25 billion per day,
We cannot promise a 100% chance of success, but we've maximized
the probability of success," said Mango.
Bourla made the decision to spend $1 billion on the project, so
if the vaccine works, it can be
made available this autumn.
At current rates, the US economy is losing about $40 billion a
week.
--------------------
STAT : 2 doses may be needed
#Post#: 247--------------------------------------------------
Re: takes over a year (Jan.2020)
By: gsgs Date: August 1, 2020, 11:46 pm
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Aug02 , > Russia preparing mass vaccination against #coronavirus
for October -
teachers and doctors first, Fauci concerned they are not testing
enough
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Jul28 , Nach den Plänen von Biontech sollen im Erfolgsfall bis
Ende des Jahres zunächst 100 Millionen
Impfstoffdosen weltweit geliefert werden. Bis Ende 2021 streben
Biontech und der
US-Pharmakonzern Pfizer an, mehr als 1,3 Milliarden weitere
Dosen bereitzustellen.
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Aug03
HTML https://www.forbes.com/sites/stevensalzberg/2020/08/02/start-vaccinating-now/
We Should Consider Starting Covid-19 Vaccinations Now
Steven Salzberg
> why not start administering millions of doses right now? We
should. [without phase 3]
{the risk from side effects being lower than the risk from COVID
due to vaccine-delays}
# I was wondering, why this hadn't been widely discussed already
since February.
# Also, the number of people/animals in the phases and the
number of phases,
# that should all have been optimized for this situation
# and not just been taken from previous regulations
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Aug.09
EU-Gesundheitsministerin Kyriakides hofft, dass in sechs Monaten
ein #Corona-Impfstoff zur Verfügung steht.
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Aug.11
Russland hat einen Impfstoff gegen das #Coronavirus für die
breite Verwendung zugelassen.
Die Testphase wurde allerdings verkürzt.
Russia registers a COVID-vaccine for brought usage.
The testphase has been shortened.
Putin's daughter is already vaccinated with 2 shots
Russia hoped to launch mass production within weeks and turn out
“several million”
doses per month by 2021.
# So, presumably they have not millions of doses this year and
they are
# basically doing what others call "phase 3" although probably
# with more people
HCWs can volunteer to get it first
--------------------------------------------
Russia claimed today it had approved a COVID-19 vaccine
- tested in just 76 people
- may be given to “a small number of citizens from vulnerable
groups,”
- cannot be used widely until 2021
HTML https://www.sciencemag.org/news/2020...-press-release
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Brazil and Israel are interested in the vax (to buy it ?!)
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Aug13
Das RKI rechnet nicht damit, dass ein Impfstoff bereits im
Herbst 2020 zur Verfügung stehen wird“:
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Curevac schließt die beschleunigte Zulassung des möglichen
Corona-Impfstoffes nicht aus.
Politische Entscheidung.
Die Ergebnisse der kürzlich gestarteten klinischen Erprobung des
Impfstoffkandidaten
sollen demnach im Herbst veröffentlicht werden. Die Zulassung
sei nach bisheriger
Planung für die erste Hälfte kommenden Jahres geplant.
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