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   DIR Return to: TYSABRI (natalizumab)
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       #Post#: 996--------------------------------------------------
       (Abst.) Asymptomatic PML during Tysabri therapy with treatment
   DIR By: agate
       Date: November 8, 2015, 12:30 am
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       It's unsettling that a person can have asymptomatic PML. This
       abstract describes such a case, in an MS patient taking Tysabri.
       From PubMed, November 7, 2015:
       --- Quote ---
       > J Clin Neurosci. 2015 Nov 2. pii: S0967-5868(15)00517-2.
       >
       > Asymptomatic progressive multifocal leukoencephalopathy during
       natalizumab therapy with treatment
       >
       > Fabis-Pedrini MJ1, Xu W2, Burton J1, Carroll WM1, Kermode AG3.
       >
       > Author information
       >
       > 1Centre for Neuromuscular and Neurological Disorders, Western
       Australian Neuroscience Research Institute, The University of
       Western Australia, Sir Charles Gairdner Hospital, 4th Floor, A
       Block, QEII Medical Centre, Verdun Street, Nedlands, WA 6009,
       Australia.
       > 2Centre for Neuromuscular and Neurological Disorders, Western
       Australian Neuroscience Research Institute, The University of
       Western Australia, Sir Charles Gairdner Hospital, 4th Floor, A
       Block, QEII Medical Centre, Verdun Street, Nedlands, WA 6009,
       Australia; Department of Neurology, The Third Affiliated
       Hospital of Sun Yat-sen University, Guangzhou, China.
       > 3Centre for Neuromuscular and Neurological Disorders, Western
       Australian Neuroscience Research Institute, The University of
       Western Australia, Sir Charles Gairdner Hospital, 4th Floor, A
       Block, QEII Medical Centre, Verdun Street, Nedlands, WA 6009,
       Australia; Institute of Immunology and Infectious Diseases,
       Murdoch University, Murdoch, WA 6150, Australia. Electronic
       address: kermode@me.com.
       >
       >
       > We report a case of asymptomatic progressive multifocal
       leukoencephalopathy (PML) detected on regular MRI screening in a
       40-year-old patient with subsequent benign course with 12-months
       follow-up.
       >
       > The patient had a history of aggressive inflammatory multiple
       sclerosis, prior mitoxantrone therapy, Stratify John Cunningham
       Virus test positivity (Quest Diagnostics, Madison, NJ, USA), and
       5 years of natalizumab monotherapy. The initial MRI detection of
       PML was both atypical and subtle. Early diagnosis and
       intervention, and pre-emptive treatment for immune
       reconstitution inflammatory syndrome with high dose steroids, as
       well as empirical mirtazapine and mefloquine, were associated
       with a benign PML disease course and outcome.
       --- End Quote ---
       The abstract can be seen here
  HTML http://www.ncbi.nlm.nih.gov/pubmed/26541323.
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