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   DIR Return to: TYSABRI (natalizumab)
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       #Post#: 996--------------------------------------------------
       (Abst.) Asymptomatic PML during Tysabri therapy with treatment
       By: agate Date: November 8, 2015, 12:30 am
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       It's unsettling that a person can have asymptomatic PML. This
       abstract describes such a case, in an MS patient taking Tysabri.
       From PubMed, November 7, 2015:
       [quote]J Clin Neurosci. 2015 Nov 2. pii: S0967-5868(15)00517-2.
       Asymptomatic progressive multifocal leukoencephalopathy during
       natalizumab therapy with treatment
       Fabis-Pedrini MJ1, Xu W2, Burton J1, Carroll WM1, Kermode AG3.
       Author information
       1Centre for Neuromuscular and Neurological Disorders, Western
       Australian Neuroscience Research Institute, The University of
       Western Australia, Sir Charles Gairdner Hospital, 4th Floor, A
       Block, QEII Medical Centre, Verdun Street, Nedlands, WA 6009,
       Australia.
       2Centre for Neuromuscular and Neurological Disorders, Western
       Australian Neuroscience Research Institute, The University of
       Western Australia, Sir Charles Gairdner Hospital, 4th Floor, A
       Block, QEII Medical Centre, Verdun Street, Nedlands, WA 6009,
       Australia; Department of Neurology, The Third Affiliated
       Hospital of Sun Yat-sen University, Guangzhou, China.
       3Centre for Neuromuscular and Neurological Disorders, Western
       Australian Neuroscience Research Institute, The University of
       Western Australia, Sir Charles Gairdner Hospital, 4th Floor, A
       Block, QEII Medical Centre, Verdun Street, Nedlands, WA 6009,
       Australia; Institute of Immunology and Infectious Diseases,
       Murdoch University, Murdoch, WA 6150, Australia. Electronic
       address: kermode@me.com.
       We report a case of asymptomatic progressive multifocal
       leukoencephalopathy (PML) detected on regular MRI screening in a
       40-year-old patient with subsequent benign course with 12-months
       follow-up.
       The patient had a history of aggressive inflammatory multiple
       sclerosis, prior mitoxantrone therapy, Stratify John Cunningham
       Virus test positivity (Quest Diagnostics, Madison, NJ, USA), and
       5 years of natalizumab monotherapy. The initial MRI detection of
       PML was both atypical and subtle. Early diagnosis and
       intervention, and pre-emptive treatment for immune
       reconstitution inflammatory syndrome with high dose steroids, as
       well as empirical mirtazapine and mefloquine, were associated
       with a benign PML disease course and outcome.[/quote]
       The abstract can be seen here
  HTML http://www.ncbi.nlm.nih.gov/pubmed/26541323.
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