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       #Post#: 989--------------------------------------------------
       (Abst.) Alemtuzumab for MS: Long-term follow-up in multi-center
       cohort
   DIR By: agate
       Date: October 30, 2015, 3:20 pm
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       From Multiple Sclerosis Journal, October 30, 2015:
       --- Quote ---
       > Alemtuzumab for multiple sclerosis: Long term follow-up in a
       multi-centre cohort
       >
       > MD Willis
       > Institute of Psychological Medicine and Clinical Neuroscience,
       Cardiff University, University Hospital of Wales, UK/Department
       of Neurology, University Hospital of Wales, UK
       >
       > KE Harding
       > Institute of Psychological Medicine and Clinical Neuroscience,
       Cardiff University, University Hospital of Wales, UK/Department
       of Neurology, University Hospital of Wales, UK
       >
       > TP Pickersgill
       > Department of Neurology, University Hospital of Wales, UK
       >
       > M Wardle
       > Department of Neurology, University Hospital of Wales, UK
       >
       > OR Pearson
       > Department of Neurology, Morriston Hospital, UK
       >
       > NJ Scolding
       > Department of Neurology, Southmead Hospital, UK
       >
       > J Smee
       > Department of Neurology, University Hospital of Wales, UK
       >
       > NP Robertson⇑
       > Institute of Psychological Medicine and Clinical Neuroscience,
       Cardiff University, University Hospital of Wales, UK/Department
       of Neurology, University Hospital of Wales, UK
       > Institute of Psychological Medicine and Clinical Neuroscience,
       Cardiff University, University Hospital of Wales, Heath Park,
       Cardiff, CF14 4XN, UK.
       >
       > Background:
       >
       > Alemtuzumab has recently been approved for treatment of
       relapsing MS, but concerns remain about its use since long-term
       studies of adverse events remain limited. Furthermore, a clear
       understanding of its application and durability of effect in
       clinical practice has yet to evolve.
       >
       > Objectives:
       >
       > To investigate long-term efficacy and safety outcomes in a
       multicentre cohort of patients treated with alemtuzumab.
       >
       > Methods:
       >
       > Patients treated from 2000 and followed-up at three regional
       centres were identified. Baseline and prospective data were
       obtained and validated by clinical record review.
       >
       > Results:
       >
       > One hundred patients were identified with a mean follow-up of
       6.1 years (range 1–13). Forty patients were retreated with at
       least one further treatment cycle. Annualized relapse rates fell
       from 2.1 to 0.2 (p<0.0001) post-treatment and were sustained for
       up to eight years of follow-up.
       >
       > Mean change in EDSS score was +0.14. Forty-seven patients
       developed secondary autoimmunity.
       >
       > Conclusion:
       >
       > Observed reduction in relapse rates reflected those reported
       in clinical trials, but we were unable to corroborate previous
       observations of disability reversal. 40% of patients required
       additional treatment cycles.
       >
       > Autoimmune adverse events were common, occurring at a higher
       rate than previously reported, but were largely predictable, and
       could be managed effectively within a rigorous monitoring
       regime.
       --- End Quote ---
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