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#Post#: 73--------------------------------------------------
The worms again
DIR By: agate
Date: December 14, 2013, 7:37 pm
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For a while there's been talk of having MS patients ingest
certain worms (helminths) might be helpful. Though this isn't
the most agreeable of possible cures, the researchers are still
working on it.
In fact, they took some MS patients and had them drink a sports
drink with the worms in it.
There is an article in the Winter 2013-14 issue of Momentum
Magazine
HTML http://www.momentummagazineonline.com/gut-reaction-ms/,
"A gut
reaction to MS," that tells more about it and about the gut
microbiome currently being mapped by the National Institutes of
Health (Human Microbiome Project,
HTML http://commonfund.nih.gov/hmp
HTML http://commonfund.nih.gov/hmp.
#Post#: 366--------------------------------------------------
Treating autoimmune diseases with the help of the pig whipworm
genome
DIR By: agate
Date: June 25, 2014, 6:37 pm
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Worms are getting attention again. Medical News Today's
article,"Treating Autoimmune Diseases with the Help of the Pig
Whipworm Genome"
HTML http://www.medicalnewstoday.com/releases/278622.php?tw
(June 24,
2014), discusses research published in Nature Genetics
indicating that pig whipworm larvae have a role in inhibiting
inflammation and have been shown to be helpful in autoimmune
disorders such as MS.
#Post#: 376--------------------------------------------------
Re: The worms again
DIR By: agate
Date: July 2, 2014, 6:39 pm
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There seems to be a question about just how good an idea it is
to continue deworming populations vulnerable to helminth-related
morbidity if some worms are now being ingested as a means of
treating autoimmune diseases--MS, for example.
From PubMed, July 2, 2014:
--- Quote ---
> Lancet Infect Dis. 2014 Jun 26.
>
> Helminth therapy or elimination: epidemiological,
immunological, and clinical considerations
>
> Wammes LJ1, Mpairwe H2, Elliott AM3, Yazdanbakhsh M4.
>
> Author information
>
> 1Department of Parasitology, Leiden University Medical Center,
Leiden, Netherlands.
> 2MRC/Uganda Virus Research Institute, Uganda Research Unit on
AIDS, Entebbe, Uganda.
> 3MRC/Uganda Virus Research Institute, Uganda Research Unit on
AIDS, Entebbe, Uganda; London School of Hygiene and Tropical
Medicine, London, UK.
> 4Department of Parasitology, Leiden University Medical Center,
Leiden, Netherlands. Electronic address: m.yazdanbakhsh@lumc.nl.
>
> Deworming is rightly advocated to prevent helminth-induced
morbidity. Nevertheless, in affluent countries, the deliberate
infection of patients with worms is being explored as a possible
treatment for inflammatory diseases. Several clinical trials are
currently registered, for example, to assess the safety or
efficacy of Trichuris suis ova in allergies, inflammatory bowel
diseases, multiple sclerosis, rheumatoid arthritis, psoriasis,
and autism, and the Necator americanus larvae for allergic
rhinitis, asthma, coeliac disease, and multiple sclerosis.
Studies in animals provide strong evidence that helminths can
not only downregulate parasite-specific immune responses, but
also modulate autoimmune and allergic inflammatory responses and
improve metabolic homoeostasis. This finding suggests that
deworming could lead to the emergence of inflammatory and
metabolic conditions in countries that are not prepared for
these new epidemics. Further studies in endemic countries are
needed to assess this risk and to enhance understanding of how
helminths modulate inflammatory and metabolic pathways. Studies
are similarly needed in non-endemic countries to move
helminth-related interventions that show promise in animals, and
in phase 1 and 2 studies in human beings, into the therapeutic
development pipeline.
>
> PMID: 24981042
--- End Quote ---
The abstract can be seen here
HTML http://www.ncbi.nlm.nih.gov/pubmed/24981042.
#Post#: 2832--------------------------------------------------
Perspectives about helminth therapy from people with MS
DIR By: agate
Date: March 4, 2020, 4:09 pm
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From PubMed March 4, 2020), "Perspectives of people with
multiple sclerosis about helminth therapy":
HTML https://www.ncbi.nlm.nih.gov/pubmed/32123528
#Post#: 2938--------------------------------------------------
Randomized double-blinded placebo-controlled trial of hookworm
treatment for MS
DIR By: agate
Date: June 15, 2020, 8:03 pm
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From JAMA Neurology (June 15, 2020)--"Hookworm treatment for
relapsing multiple sclerosis: A randomized double-blinded
placebo-controlled trial":
HTML https://bit.ly/2MZ6dLp
#Post#: 2940--------------------------------------------------
Doubts about the worms expressed in JAMA Neurology?
DIR By: agate
Date: June 18, 2020, 1:21 am
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It sounds as if some investigators have doubts about the
worms/helminths.
The same issue of JAMA Neurology (see previous post) contains an
article (unfortunately with no abstract available) entitled
"Keep the worms in the mud" written by researchers at the Mellen
MS Center at the Cleveland Clinic.
#Post#: 3102--------------------------------------------------
Worms may not be so useful after all
DIR By: agate
Date: November 28, 2020, 7:44 pm
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Doubts about the usefulness of helminth therapy in Multiple
Sclerosis Journal (October 1, 2020)--"A critical analysis of
helminth immunotherapy in multiple sclerosis":
HTML https://journals.sagepub.com/doi/full/10.1177/1352458519899040
The conclusion:
--- Quote ---
> Although there are only a limited number of studies that have
tested whether HIT can have therapeutic effects once disease is
established, there are indications of beneficial effect using
some HIT regimens. However, controlled clinical trials have so
far failed to recapitulate these effects and do not support the
use of HIT for treatment of established MS.
--- End Quote ---
#Post#: 4213--------------------------------------------------
Here are the worms once again, turning up like a bad penny
DIR By: agate
Date: November 8, 2023, 1:36 am
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More on worms and MS--in Medical News Today (November 7, 2023),
"Can parasites help reduce the risk of MS"?
HTML https://bit.ly/3MzCgRg
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