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#Post#: 668--------------------------------------------------
Coffee may protect against MS
DIR By: agate
Date: February 27, 2015, 6:44 pm
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From MedPage Today, February 26, 2015:
--- Quote ---
> Coffee May Protect Against MS
>
> by Kristina Fiore
> Staff Writer, MedPage Today
>
> Filling up on coffee may protect against development of
multiple sclerosis, according to findings from two cohort
studies.
>
> In both studies, patients with the highest levels of coffee
consumption had significantly lower risks of developing MS over
various time periods, Ellen Mowry, MD, of Johns Hopkins, and
colleagues reported in an early-release abstract from this
year's American Academy of Neurology meeting.
>
>
> The authors suspect that the caffeine in coffee is responsible
for the relationship.
>
> "Caffeine could be an attractive compound given its apparent
benefit in protecting against Parkinson's and Alzheimer's
diseases," Mowry said in an email to MedPage Today. "The exact
mechanism by which it does so in those diseases is unclear, and
if caffeine is confirmed to be protective in MS, it may still be
acting via a different mechanism."
>
> Although the balance of evidence linking coffee and
Parkinson's and Alzheimer's falls on the side of benefit, the
literature on coffee and MS is far less clear.
>
> "The literature is a bit limited with respect to coffee and MS
risk," Mowry said. "One study showed no apparent association
between the two, although notably that study had fewer patients
than ours."
> She noted that her study was limited because it "asked
patients about prior coffee intake after the diagnosis of MS was
made, such that it is possible that 'recall bias' played a role.
For example, perhaps patients with MS subconsciously
underestimated their previous coffee intake more than people
without MS."
>
> She and colleagues conducted two population-based,
case-control studies. One was a Swedish study that included
1,629 MS cases and 2,087 controls. The other was a Kaiser
Permanente Northern California study of 584 cases and 581
controls.
>
> In the Swedish cohort, they found that drinking coffee was
associated with a reduced odds of developing MS compared with
drinking no coffee at all.
>
> The reduction in risk was greatest for those who drank the
most coffee. Those who reported having at least six cups a day
or more had a 33% reduction in risk of developing MS compared
with not drinking any coffee (OR 0.67, 95% CI 0.47 to 0.95).
>
> The researchers also found that those who had high coffee
consumption for either 5 or 10 years before the index year had a
lower likelihood of developing MS:
>
> 5 years: OR 0.70, 95% CI 0.50-0.99
> 10 years: OR 0.72, 95% CI 0.48-1.06
>
> Similar results were seen in the northern California study.
People who drank at least four cups of coffee per day prior to
the index year also had a 33% reduction in risk of MS compared
with those who drank no coffee, they found (OR 0.67, 95% CI
0.47-0.95).
>
> A possible explanation for the association is that the
caffeine in the coffee has neuroprotective properties and may
suppress the production of proinflammatory cytokines, the
researchers said.
>
> Although the relationship requires further study, Mowry said
coffee and caffeine should also be studied for potential effects
[on?] relapses and long-term disability in MS.
>
> _________________
> The study was supported by the Swedish Medical Research
Council, the Swedish Research Council for Health, Working Life
and Welfare, Knut and Alice Wallenberg, AFA, the Swedish Brain
Foundation, the Swedish Association for Persons with
Neurological Disabilities, and the NIH.
--- End Quote ---
#Post#: 757--------------------------------------------------
(AAN) Greater coffee consumption associated w/reduced odds of MS
DIR By: agate
Date: April 30, 2015, 6:11 pm
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Presented at the recent annual AAN conference in Washington, DC:
--- Quote ---
> [S45.004] Greater Consumption of Coffee is Associated with
Reduced Odds of Multiple Sclerosis
>
>
> Ellen Mowry,1Anna K. Hedstrom,2Milena A.
Gianfrancesco,3Xiaorong Shao,3Catherine A. Schaefer,4Lisa
Barcellos,3Tomas Olsson,5Lars Alfredsson2
>
> 1Baltimore, MD, USA, 2Stockholm, Sweden, 3Berkeley, CA, USA,
4Oakland, CA, USA, 5Solna, Sweden.
>
> OBJECTIVE:
>
> We sought to determine if coffee consumption is associated
with MS risk.
>
> BACKGROUND:
>
> Previous studies on caffeine consumption and MS risk have been
inconclusive. Caffeine intake has been associated with reduced
odds of Parkinson’s and Alzheimer’s diseases and thus may be
neuroprotective.
>
> DESIGN/METHODS:
>
> Using two population-based case-control studies (a Swedish
study of 1,629 incident cases and 2,807 controls, and a Kaiser
Permanente Northern California (United States) study of 584
prevalent cases and 581 controls), the association of coffee
consumption prior to disease onset with the odds of MS was
evaluated in multivariate unconditional logistic regression
models, adjusted for potential confounding factors, including
(but not limited to) age, sex, smoking, body mass index, and sun
exposure habits.
>
> RESULTS:
>
> In the Swedish cohort, coffee consumption was associated with
reduced odds of MS compared to subjects who reported no coffee
consumption. Consuming at least 6 cups of coffee daily during
the index year was associated with an adjusted odds ratio (OR)
for MS of 0.67 (95% CI 0.47-0.95). The corresponding ORs for
those who reported high coffee consumption 5 or 10 years before
the index year were 0.70 (95% CI 0.50-0.99) and 0.72 (95% CI
0.48-1.06). In the Kaiser Permanente Northern California study,
among those who consumed 4 or more cups of coffee daily prior to
the index year, the OR for MS was also 0.67 (95% CI 0.47-0.95).
>
> CONCLUSIONS:
>
> High coffee consumption is associated with reduced odds of MS.
Caffeine has neuroprotective properties and seems to suppress
the production of proinflammatory cytokines, which may be
mechanisms that explain the observed association.
>
> _________________
> Study Supported by:
>
> Swedish Medical Research Council; Swedish Research Council for
Health, Working Life and Welfare; Knut and Alice Wallenberg,
AFA, and Swedish Brain Foundations; Swedish Association for
Persons with Neurological Disabilities; NIH/NINDS R01 NS049510;
R01 NS0495103; NIH/NIAID R01 A1076544
>
> ______
> Category - Neuroepidemiology: MS and CNS Inflammatory Disease
>
> Session: S45: Platform Session: Neuroepidemiology: Multiple
Sclerosis, Cerebrovascular, and Aging (1:00 PM-2:45 PM)
> Date/Time: Thursday, April 23, 2015 - 1:45 pm
--- End Quote ---
The abstract can be seen here
HTML http://www.abstracts2view.com/aan/view.php?nu=AAN15L1_S45.004.
#Post#: 1131--------------------------------------------------
Drinking more coffee may stave off MS
DIR By: agate
Date: March 4, 2016, 8:11 pm
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Correlation doesn't imply causation, as they say. ...
From Medical News Today, March 4, 2016:
--- Quote ---
> Drinking more coffee may stave off multiple sclerosis
>
>
> Written by Yvette Brazier
>
> If you are trying to cut down on your six cups of coffee a
day, think again. Research published in the Journal of
Neurology, Neurosurgery and Psychiatry indicates that caffeine's
neuroprotective and anti-inflammatory properties may lower the
risk of developing multiple sclerosis.
>
> The National Institute of Neurological Diseases and Stroke
(NINDS) describes multiple sclerosis (MS) as "an unpredictable
disease of the central nervous system," symptoms of which can
range from fairly benign to devastating. MS disrupts
communication between the brain and the rest of the body.
>
> Coffee contains over 1,000 biologically active compounds,
including the central nervous system (CNS) stimulant, caffeine.
Caffeine's neuroprotective properties can suppress the
production of chemicals involved in the inflammatory response.
>
> Previous studies have associated a high coffee intake with
lower rates of cardiovascular disease (CVD), stroke and type 2
diabetes. In animal models of Alzheimer's disease, caffeine has
helped to protect against blood-brain barrier leakage.
>
> Two representative population studies provided data for the
current research.
>
> Dr. Anna Hedström, of the Institute of Environmental Medicine,
Karolinska Institutet in Stockholm, Sweden, and colleagues
compared 1,620 Swedish adults with MS with 2,788 healthy
subjects, matched for age and sex.
>
> In the US, teams from Johns Hopkins University in Baltimore,
MD, the University of California-Berkeley and the Kaiser
Permanente Division of Research in Oakland, CA, compared 1,159
people with MS with 1,172 healthy participants.
>
> Six cups a day linked to 31% lower risk of MS
> In both studies, participants provided information about their
coffee drinking.
>
> The Swedish participants quantified their usual daily intake
in cups at different ages, from 15-19 years until they were 40
years and over.
>
> In the US study, participants gave information about their
maximum daily consumption. Those who drank one or more cups also
recalled at what age they started drinking coffee regularly.
>
> The researchers then estimated coffee consumption at and
before the onset of symptoms in those with MS, and they compared
the results with those of the healthy groups.
>
> There was a consistently higher risk of MS among those who
drank fewer cups of coffee every day in both studies, even after
adjusting for factors such as smoking and weight during
adolescence.
>
> In the Swedish study, coffee consumption correlated with a
lower risk of MS both at the onset of symptoms and 5-10 years
beforehand. Those who consumed over six cups (900 ml+) daily had
a 28-30% lower risk.
>
> The US study revealed a 26-31% reduction in risk among those
who drank above 948 ml daily at least 5 years before and at the
start of symptoms, compared with those who never drank coffee.
>
> Findings indicate that the more coffee people consume, the
lower their risk of MS.
>
> The authors caution that a causative link cannot be confirmed,
since this was an observational study.
>
> 'Role of coffee warrants further investigation'
>
> Limitations include the possibility that patients with MS
changed their coffee consumption some time between receiving a
diagnosis and giving the information, potentially influencing
the results. Participants might also not have recalled their
coffee consumption accurately.
>
> The effects could also be due to another chemical component of
coffee rather than caffeine. The team calls for further
research.
>
> Their findings support those of previous animal studies of MS,
and they strengthen existing evidence that caffeine protects
against neurodegenerative diseases such as Alzheimer's and
Parkinson's disease.
>
> In a linked editorial, Dr. Elaine Kingwell and Dr. José Maria
Andreas Wijnands, of the Faculty of Medicine, University of
British Columbia in Vancouver, Canada, point to inconsistencies
in previous studies, but they express the hope that a better
understanding of MS etiology may lead to novel MS therapies.
>
> They write:
>
> "Although it remains to be shown whether drinking coffee can
prevent the development of MS, the results of these thorough
analyses add to the growing evidence for the beneficial health
effects of coffee. [...] The role of coffee in the development
of MS clearly warrants further investigation, as do the
mechanisms that underlie the relationship."
>
> The researchers note that while the findings do not confirm
that coffee drinking can prevent MS, they add to growing
evidence that coffee may be good for health.
>
>
--- End Quote ---
The article is available here
HTML http://www.medicalnewstoday.com/articles/307370.php?tw.
#Post#: 1133--------------------------------------------------
Re: Coffee may protect against MS
DIR By: agate
Date: March 5, 2016, 8:36 pm
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The abstract for the two studies mentioned in the previous post
(Sweden and US):
HTML http://www.ncbi.nlm.nih.gov/pubmed/26940586
From PubMed, March 5, 2016.
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