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       #Post#: 4963--------------------------------------------------
       (Abst.) Assessment of changes in fatigue & cognitive functio
       ning in the absence of progression independent of relapse.. 
       By: agate Date: October 18, 2025, 12:45 am
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       This is an abstract of a study by several authors who are well
       known in MS research.
       From PubMed (October 17, 2025)--"Assessment of changes in
       fatigue and cognitive functioning in the absence of progression
       independent of relapse activity":
  HTML https://pubmed.ncbi.nlm.nih.gov/41101250/
       Recently the PIRA category (progression independent of relapse
       activity) has been cropping up in MS literature. However, the
       results of this study seem to indicate that subjects in that
       category were still progressing since the results showed that
       [quote][font=BlinkMacSystemFont]Participants with no PIRA are
       still experiencing cognitive worsening and fatigue worsening,
       and the rate of worsening is similar to those with
       PIRA.[/font][/quote][font=BlinkMacSystemFont][/font]
       [font=BlinkMacSystemFont][/size][/font]
       [font=BlinkMacSystemFont][/size]Wouldn't this fact indicate a
       need to reassess the PIRA category?[/font]
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