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       #Post#: 4849--------------------------------------------------
       Thiazide diuretics
       By: agate Date: June 28, 2025, 1:37 am
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       MS sometimes involves "gravitational edema," or so I was told
       long ago when I ran across a photo of someone with it who looked
       a bit like me and I asked the neuro about it. Fluid collects and
       you swell up.
       Over many years I've been taking a thiazide diuretic to remedy
       this problem. I get fewer vision problems and better mobility
       from taking it, spread out in small doses over 24 hours.
       Amazingly too it seems to help to prevent kidney stones.
       For some time now I've been getting along on a reduced dosage of
       it--from 100 mg/day to 50mg/day, and once again now I'm reducing
       the dosage, down to 37.5mg/day. I'm taking that in the form of
       12.5 mg 3 times in 24 hours, spread out at intervals of
       approximately 8 hours.
       If I swell up too much or have even the slightest sign of kidney
       stone pain, I'm apt to resume the old dosage.
       Kidney stone pain is one of the worst kinds of pain I've ever
       had.
       I'm not recommending this medicine (hydrochlorothiazide is the
       one I'm on now but there are others that have similar effects)
       to anyone with MS. But it has helped me.
       #Post#: 4875--------------------------------------------------
       Re: Thiazide diuretics--update
       By: agate Date: July 22, 2025, 12:56 am
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       It's been almost a month now since I reduced the HCTZ dosage by
       12.5mg. So far, so good.
       In fact, I feel somewhat stronger. Or maybe it is just that
       there haven't been any major spells of hot weather lately.
       I did have a couple of abnormal lab test results that were
       significant enough for the doctor to propose a drug to help with
       proteinuria.
       I had proteinuria only just before being diagnosed with Type 2
       diabetes, many years ago. The tests have been normal ever
       since--and so this abnormal test result is surprising. It might
       or might not have some connection with the change in the HCTZ
       dosage.
       I haven't yet learned what drug is being considered but have let
       the doctor know that I'd like to wait a while and see if I can
       have a normal test result after a while.
       I'm of the opinion--and some experts are of the same
       opinion--that people my age should probably be very cautious
       about starting any new drug.
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