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       #Post#: 388--------------------------------------------------
       (Abst.) PML
       By: agate Date: July 13, 2014, 9:35 pm
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       A concise description of PML is provided here. From PubMed, July
       13, 2014:
       [quote]Handb Clin Neurol. 2014;123C:357-376.
       Progressive multifocal leukoencephalopathy
       Berger JR.
       Author information
       Department of Neurology and Department of Medicine, University
       of Kentucky College of Medicine, Lexington, KY, USA. Electronic
       address: jrbneuro@email.uky.edu.
       Progressive multifocal leukoencephalopathy (PML) is a
       demyelinating disorder due to an ubiquitous polyomavirus,
       referred to as JC virus. Prior to the human immunodeficiency
       virus (HIV)/acquired immunodeficiency syndrome (AIDS) pandemic,
       it was a disorder seen predominantly in individuals with
       underlying lymphomas and leukemias, in particular, B-cell
       malignancies. In the pre-antiretroviral therapy era of the
       HIV/AIDS pandemic, it ultimately developed in approximately 5%
       of all infected individuals.
       In 2005, following the recognition that it may complicate the
       use of natalizumab, an α4β1 integrin inhibitor, used
       in the treatment of multiple sclerosis and inflammatory bowel
       disorders, it achieved even greater notoriety. PML is
       characterized by a triad of histopathologic findings,
       demyelination, bizarre astrocytes, and enlarged oligodendroglial
       nuclei. JC virus leads to demyelination by establishing a lytic
       infection of the oligodendrocytes. The clinical features are
       diverse and depend on the region of the brain affected. The
       disease is often heralded by cognitive and behavioral changes,
       language disturbances, weakness, or visual deficits. The
       diagnosis can often be established by cranial magnetic resonance
       imaging findings coupled with positive polymerase chain reaction
       for JC virus in the cerebrospinal fluid. To date, no treatment
       has been convincingly effective.[/quote]
       The abstract can be seen here
  HTML http://www.ncbi.nlm.nih.gov/pubmed/25015495.
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