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#Post#: 3095--------------------------------------------------
(Abst.) PML and the spectrum of JC virus-related disease
By: agate Date: November 22, 2020, 3:44 pm
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From PubMed (November 22, 2020)--"Progressive multifocal
leucoencephalopathy and the spectrum of JC virus-related
disease," an abstract of a study appearing in Nature and done by
investigators at the National Institutes of Health:
HTML https://pubmed.ncbi.nlm.nih.gov/33219338/
Excerpt from the abstract:
[quote][font=BlinkMacSystemFont]Antiretroviral therapies greatly
reduce the risk of HIV-related PML, but many modern treatments
for cancers, organ transplantation and chronic inflammatory
disease cause immunosuppression that can be difficult to
reverse. These treatments - most notably natalizumab for
multiple sclerosis - have led to a surge of iatrogenic PML. The
spectrum of presentations of JCV-related disease has evolved
over time and may challenge current diagnostic criteria.
Immunotherapeutic interventions, such as use of checkpoint
inhibitors and adoptive T cell transfer, have shown promise but
caution is needed in the management of immune reconstitution
inflammatory syndrome, an exuberant immune response that can
contribute to morbidity and
death.[/font][font=BlinkMacSystemFont][/size]
[/font][font=Verdana][/size][/font][/quote][font=Verdana][/font]
[font=Verdana][/size][/font]
[font=Verdana][/size][Emphasis added][/font]
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