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       #Post#: 3095--------------------------------------------------
       (Abst.) PML and the spectrum of JC virus-related disease
   DIR By: agate
       Date: November 22, 2020, 3:44 pm
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       From PubMed (November 22, 2020)--"Progressive multifocal
       leucoencephalopathy and the spectrum of JC virus-related
       disease," an abstract of a study appearing in Nature and done by
       investigators at the National Institutes of Health:
  HTML https://pubmed.ncbi.nlm.nih.gov/33219338/
       Excerpt from the abstract:
       --- Quote ---
       > Antiretroviral therapies greatly reduce the risk of
       HIV-related PML, but many modern treatments for cancers, organ
       transplantation and chronic inflammatory disease cause
       immunosuppression that can be difficult to reverse. These
       treatments - most notably natalizumab for multiple sclerosis -
       have led to a surge of iatrogenic PML. The spectrum of
       presentations of JCV-related disease has evolved over time and
       may challenge current diagnostic criteria. Immunotherapeutic
       interventions, such as use of checkpoint inhibitors and adoptive
       T cell transfer, have shown promise but caution is needed in the
       management of immune reconstitution inflammatory syndrome, an
       exuberant immune response that can contribute to morbidity and
       death.[/size] [/size]
       --- End Quote ---
       [/size]
       [/size][Emphasis added]
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