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   DIR Return to: OCREVUS (ocrelizumab)
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       #Post#: 2466--------------------------------------------------
       Fulminant hepatitis associated w/Echovirus 25 during Ocrevus
       treatment...
   DIR By: agate
       Date: April 8, 2019, 7:03 pm
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       I may be giving too much attention to rare, anecdotal instances
       of adverse effects of the MS disease-modifying drugs, but here
       is another one. This MS patient was taking Ocrevus but ended up
       getting a liver transplant--and stopping the Ocrevus.  This is
       from JAMA Neurology (April 8, 2019), "Fulminant hepatitis
       associated with Echovirus 25 during treatment with ocrelizumab
       for multiple sclerosis":
  HTML http://bit.ly/2WXuNQ6
       This is from the discussion:
       --- Quote ---
       >
       > Because ocrelizumab is a novel, high-efficacy
       disease-modifying therapy for MS, it will probably be
       extensively used. However, it may impair clearance of
       enterovirus infections via B-cell depletion. Thus, in the case
       of compatible symptoms, tests should be conducted for
       enteroviruses. Given the bimodal clinical presentation (ie, the
       patient had a severe rebound of liver enzyme levels after
       initial improvement), patients receiving ocrelizumab with
       enteroviral infection need close follow-up.
       >
       --- End Quote ---
       #Post#: 2587--------------------------------------------------
       Re: Fulminant hepatitis associated w/Echovirus 25 during Ocrevus
       treatment...
   DIR By: ewizabeth
       Date: July 17, 2019, 10:54 am
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       I was required to get tested for all forms of hepatitis prior to
       starting Ocrevus so now I know why. I was completely negative on
       all of them.
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