DIR Return Create A Forum - Home
---------------------------------------------------------
MS Speaks
HTML https://msspeaks.createaforum.com
---------------------------------------------------------
*****************************************************
DIR Return to: TYSABRI (natalizumab)
*****************************************************
#Post#: 1924--------------------------------------------------
(Abst.) Refractory epilepsy following natalizumab-associated PML
By: agate Date: December 19, 2017, 6:43 pm
---------------------------------------------------------
From PubMed, December 19, 2017:
[quote]Mult Scler Relat Disord. 2017 Dec 13;20:1-2.
Refractory epilepsy following natalizumab associated PML
Abkur TM1, Kearney H2, Hennessy MJ2.
Author information
1
Department of Neurology, Galway University Hospital, Galway,
Ireland. Electronic address: tarig1982@hotmail.com.
2
Department of Neurology, Galway University Hospital, Galway,
Ireland.
Natalizumab treatment of multiple sclerosis (MS) is associated
with a risk of developing progressive multifocal
leukoencephalopathy (PML), a rare opportunistic viral
demyelinating disease caused by reactivation of John Cunningham
virus (JCV). Herein we report a case of a 40-year-old woman who
developed refractory temporal lobe epilepsy one year after
recovery from Natalizumab-induced PML. Localisation related
epilepsy, which may be refractory in nature, as in this case
report, is a potential chronic disabling complication of PML.
Epilepsy in this context likely reflects grey matter
involvement, which may then act as cortical epileptogenic
zone.[/quote]
HTML https://www.ncbi.nlm.nih.gov/pubmed/29253743
*****************************************************