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#Post#: 1393--------------------------------------------------
MS patients may be at lower risk for other illnesses (Danish
study)
DIR By: agate
Date: September 29, 2016, 9:18 pm
---------------------------------------------------------
From Multiple Sclerosis News Today, September 19--a summary of a
paper presented at the ECTRIMS conference (September 14-17,
London):
--- Quote ---
> #ECTRIMS2016 – MS Patients May Be at Lower Risk for Other
Illnesses, Danish Study Suggests
>
> Patricia Inacio, PhD
>
> Preliminary results of a study in Danish patients with
multiple sclerosis (MS) suggest that inverse comorbidity may
exist in the MS population, lowering patients’ risk for other
types of diseases. The results were given in an oral
presentation, “Inverse comorbidity in multiple sclerosis.
Findings in a complete nationwide cohort,” at the 32nd Congress
of the European Committee for Treatment and Research in Multiple
Sclerosis (ECTRIMS), held in London (Sept. 14-17).
>
> Inverse comorbidity is a concept that defines a
lower-than-expected probability of disease (in comparison to the
general population) in individuals who have been diagnosed with
other medical conditions.
>
> Researchers, in a study financed by the Danish Multiple
Sclerosis Society, performed a combined case-control and cohort
study using a total nationwide cohort of Danish MS patients,
whose clinical disease onset was registered between 1980 and
2005. Each MS case was randomly matched to five healthy
individuals (the control group) by gender, year of birth, and
municipality on Jan. 1 in the year of MS onset (index date).
Following the study population from January 1977 until the index
date, and from the index date until December 2012, the team
assessed the occurrence of comorbidities (at the individual
level) before and after disease onset.
>
> The study included, in total, 8,947 eligible MS cases and
44,735 control cases.
>
> Researchers found a decreased risk for cerebrovascular
comorbidity in MS patients when compared to controls before the
index date — or date of disease onset — although the findings
here didn’t reach the level of statistical significance. After
the index date, researchers observed a decrease in the
occurrence of chronic lung disease (asthma and chronic
obstructive pulmonary disease [COPD]), as well as overall cancer
among MS patients. Once again, however, the results did not
reach a statistical significance.
>
> Still, findings suggest that MS patients may carry lower risks
for cerebrovascular disease before the onset of MS, and a
decreased risk for cancers and pulmonary diseases after MS
onset, hinting at a trend toward inverse comorbidity in MS
patients for certain medical conditions. But the authors state
that future studies should confirm this hypothesis.
>
> “Identification of inverse comorbidity and of its underlying
mechanisms may provide new important entry points into the
understanding of MS,” the team concluded.
--- End Quote ---
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#Post#: 1394--------------------------------------------------
Re: MS patients may be at lower risk for other illnesses (Danish
study)
DIR By: ssalimi
Date: September 30, 2016, 2:29 pm
---------------------------------------------------------
--- Quote from: agate link ---
>
> From Multiple Sclerosis News Today, September 19--a summary of
a paper presented at the ECTRIMS conference (September 14-17,
London):
>
> [quote]#ECTRIMS2016 – MS Patients May Be at Lower Risk for
Other Illnesses, Danish Study Suggests
>
> Patricia Inacio, PhD
>
> Preliminary results of a study in Danish patients with
multiple sclerosis (MS) suggest that inverse comorbidity may
exist in the MS population, lowering patients’ risk for other
types of diseases. The results were given in an oral
presentation, “Inverse comorbidity in multiple sclerosis.
Findings in a complete nationwide cohort,” at the 32nd Congress
of the European Committee for Treatment and Research in Multiple
Sclerosis (ECTRIMS), held in London (Sept. 14-17).
>
> Inverse comorbidity is a concept that defines a
lower-than-expected probability of disease (in comparison to the
general population) in individuals who have been diagnosed with
other medical conditions.
>
> Researchers, in a study financed by the Danish Multiple
Sclerosis Society, performed a combined case-control and cohort
study using a total nationwide cohort of Danish MS patients,
whose clinical disease onset was registered between 1980 and
2005. Each MS case was randomly matched to five healthy
individuals (the control group) by gender, year of birth, and
municipality on Jan. 1 in the year of MS onset (index date).
Following the study population from January 1977 until the index
date, and from the index date until December 2012, the team
assessed the occurrence of comorbidities (at the individual
level) before and after disease onset.
>
> The study included, in total, 8,947 eligible MS cases and
44,735 control cases.
>
> Researchers found a decreased risk for cerebrovascular
comorbidity in MS patients when compared to controls before the
index date — or date of disease onset — although the findings
here didn’t reach the level of statistical significance. After
the index date, researchers observed a decrease in the
occurrence of chronic lung disease (asthma and chronic
obstructive pulmonary disease [COPD]), as well as overall cancer
among MS patients. Once again, however, the results did not
reach a statistical significance.
>
> Still, findings suggest that MS patients may carry lower risks
for cerebrovascular disease before the onset of MS, and a
decreased risk for cancers and pulmonary diseases after MS
onset, hinting at a trend toward inverse comorbidity in MS
patients for certain medical conditions. But the authors state
that future studies should confirm this hypothesis.
>
> “Identification of inverse comorbidity and of its underlying
mechanisms may provide new important entry points into the
understanding of MS,” the team concluded.
--- End Quote ---
HTML https://multiplesclerosisnewstoday.com/2016/09/19/inverse-comorbidity-in-ms-patients-suggested-in-danish-study?utm_source=Multiple+Sclerosis&utm_campaign=135ee84e5b-RSS_MONDAY_EMAIL_CAMPAIGN&utm_medium=email&utm_term=0_b5fb7a3dae-135ee84e5b-71286581
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[/quote]
Very interesting. I was trying to do some research the other day
on overall cancer prevalence in people with MS due to a lot of
the new immunomodulators or immunosuppressants and most of the
stuff I found dated back before the introduction of these
medications but showed an inverse correlation. This is good that
the study goes through 2012 but more up to date data would be
useful. I fear that using these immunosuppressants might give
rise to something worse than MS. A risk I had to take when
deciding to get on the medication.
#Post#: 1395--------------------------------------------------
Re: MS patients may be at lower risk for other illnesses (Danish
study)
DIR By: agate
Date: September 30, 2016, 4:13 pm
---------------------------------------------------------
You probably know this already but there's a difference between
an immunomodulator and an immunosuppressant. Most MS drugs are
immunomodulator but a few are immunosuppressants.
I was also concerned about any tinkering with the immune system.
Maybe more is known about the immune system than I realize but
it still seems to me to be a risky business to play around with
it.
On the other hand, what else has anyone come up with for MS?
#Post#: 1396--------------------------------------------------
Re: MS patients may be at lower risk for other illnesses (Danish
study)
DIR By: ssalimi
Date: September 30, 2016, 7:10 pm
---------------------------------------------------------
--- Quote from: agate link ---
>
> You probably know this already but there's a difference
between an immunomodulator and an immunosuppressant. Most MS
drugs are immunomodulator but a few are immunosuppressants.
>
> I was also concerned about any tinkering with the immune
system. Maybe more is known about the immune system than I
realize but it still seems to me to be a risky business to play
around with it.
>
> On the other hand, what else has anyone come up with for MS?
>
--- End Quote ---
Agreed. Sad that the decision is based on picking between the
lesser of two evils. I think remyelination is the best chance we
have at stopping this disease.
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