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#Post#: 1366--------------------------------------------------
(ECTRIMS) Survival and mortality in MS: a 60-year longitudinal
population study
DIR By: agate
Date: September 18, 2016, 1:41 pm
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Presented as poster session #303 at the annual ECTRIMS
conference (London, September 14-17, 2016):
--- Quote ---
> Survival and mortality in multiple sclerosis: a 60-year
longitudinal population study
>
> H.M. Lunde1, J. Assmuss2, K.-M. Myhr3,4, L. Bø3,4, N. Grytten4
>
> 1Department of Clinical Medicine, KG Jebsen MS Research
Centre, University of Bergen, 2Competence Centre for Clinical
Research, 3Department of Neurology, Haukeland University
Hospital, The Norwegian Multiple Sclerosis Centre, 4Department
of Clinical Medicine, KG Jebsen MS Research Centre, University
of Bergen,Norway, Bergen, Norway
>
> Introduction:
>
> Mortality studies in MS have shown inconsistent results. We
aimed to investigate survival, and mortality in a population
based multiple sclerosis (MS) cohort.
>
> Methods:
>
> The study comprised all incident MS patients (N=1388) with
onset during 1953-2012 in Hordaland County, Western Norway.
Patient information was obtained from patient records at
Haukeland University Hospital and linked to the Norwegian Causes
of Death (COD) registry. Survival and patient characteristics
(sex, age, disease course) were estimated by Kaplan-Meier
analyses from birth and from disease onset. Mortality in MS
relative to the general population was examined using
standardized mortality ratio (SMR).
>
> Results:
>
> Of 1388 patients, 291 had deceased, mainly of MS (56.4 %).
Median survival age was 74.7 years in MS and 81.8 years in the
general population (p< 0.001). Women had longer median life
expectancy (77.2 years) than men (72.2 years, p=0.003) and
patients with relapsing remitting MS (RRMS) survived longer (
77.8 years) than patients with primary progressive MS (PPMS)
(71.4 years, p< 0.001). Median survival from disease onset was
longer in RRMS (42.8 years) than in PPMS (25.5 years, p< 0.001).
Overall SMR was 2.71 ( 95 % CI: 2.4, 3.0); in RRMS 2.4 ( 95 %
CI: 2.1, 2.7) and 3.9 (95 % CI: 3.1, 4.7) in PPMS. SMR from
disease onset during 1953-1974 was 3.1 (95 % CI: 2.7, 3.6),
during 1975-1996, 2.6 (95 % CI: 2.2, 3.1) and during 1997-2012:
0.7 (95 % CI: 0.3,1.5).
>
> Conclusion:
>
> The longest follow-up period of 60 years on survival and
mortality in MS is here reported. MS had a 7-year lower median
survival age than the general population. Risk of death was
almost threefold higher in MS relative to the general
population. However, an encouraging decrease in mortality was
observed during the last 40 years.
>
> _______________________
> Disclosure:
>
> Hanne Marie Bøe Lunde: nothing to disclose
> Jorg Assmuss: nothing to disclose
> Kjell-Morten Myhr: nothing to disclose
> Lars Bø: nothing to disclose
> Nina Grytten: nothing to disclose
--- End Quote ---
#Post#: 1627--------------------------------------------------
Re: (ECTRIMS) Survival and mortality in MS: a 60-year
longitudinal population study
DIR By: agate
Date: April 4, 2017, 7:16 pm
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This research has been indexed in PubMed (April 4, 2017):
"Survival and cause of death in multiple sclerosis: A 60-year
longitudinal population study"
HTML https://www.ncbi.nlm.nih.gov/pubmed/28365589
#Post#: 1634--------------------------------------------------
Re: (ECTRIMS) Survival and mortality in MS: a 60-year
longitudinal population study
DIR By: ssalimi
Date: April 10, 2017, 1:31 am
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I wish there was a way to actually establish a casual link
between MS and the various illnesses & infections that cause
mortality because of immunosupression or immunomodulation of the
body. But these are written simply as pneumonia on the death
certificate. I think mortality in MS should all have something
on the death certificate thats says "died from complications
from MS" plus whatever the specific cause was, unless it truly
is absolutely unrelated.
#Post#: 1636--------------------------------------------------
Re: (ECTRIMS) Survival and mortality in MS: a 60-year
longitudinal population study
DIR By: agate
Date: April 10, 2017, 10:16 am
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"Cause" can be a fuzzy word. If you have a chronic neurological
disorder for many years and it wears you down to the point where
you're susceptible to bedsores that get infected or to pneumonia
or to kidney infections or whatever, your official cause of
death will probably be listed as the pneumonia or whatever
infection killed you, but you probably wouldn't have died of
that "cause" if you hadn't had that chronic neurological
disorder.
#Post#: 1639--------------------------------------------------
Re: (ECTRIMS) Survival and mortality in MS: a 60-year
longitudinal population study
DIR By: agate
Date: April 11, 2017, 11:11 pm
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More on this in MedPage Today, April 11, 2017:
HTML https://www.medpagetoday.com/Neurology/MultipleSclerosis/64497
HTML https://www.medpagetoday.com/Neurology/MultipleSclerosis/64497
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