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   DIR Return to: Central Nervous system and Tissue Engineering
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       #Post#: 117--------------------------------------------------
       Hyaluronic Acid Hydrogel: A Favourable Niche for Neural Stem Cel
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       By: SSamani Date: March 27, 2015, 4:29 pm
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       Injury in the central nervous system (CNS) is very serious and
       may result in permanent disability of the patients, since it
       causes neural cell death and tissue defects. There have been no
       effective therapies so far, unfortunately. Many studies have
       already shown that neural stem cells (NSC) can be used for
       treatment of certain neurological diseases because they have the
       intrinsic ability of self-renewal. However, the effect of NSC
       grafting for neural restoration has been proven to be rather
       limited because of low viability and undesired differentiation
       in vivo.
       It is critical therefore, that creation of a suitable
       microenvironment or niche, composed of cells, blood vessels,
       growth factors and the extracellular matrix (ECM), would play an
       important role in regulating neurogenesis, survival and
       regeneration of NSC. Thus, certain biomaterials used for neural
       tissue engineering may offer a promising approach for creating
       such a microenvironment, since they provide biological scaffolds
       which can sustain the stem cells for transplantation and neural
       regrowth in vivo.
       Among those materials, the hyaluronic acid (HA)-based
       biodegradable hydrogel has been proven to mimic brain ECM
       effectively and to provide a good scaffold that is easily
       modified with different useful molecules for promoting
       regeneration
       in the injured CNS.
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