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       #Post#: 86--------------------------------------------------
       Cardiac repair using chitosan-hyaluronan/silk fibroin patches
       By: SSamani Date: February 21, 2015, 1:36 pm
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       [font=verdana]
       [center]Cardiac repair using chitosan-hyaluronan/silk fibroin
       patches in a rat heart model with myocardial infarction
       Carbohydrate Polymers 92 (2013) 591– 597[/center]
       Abstract
       The cardiac repair of myocardial infarction (MI) hearts of rats
       using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac
       patches was examined after eight weeks of implantation. Rats
       with implantations of chitosan-HYA/SF patches (CHS group)
       significantly (P <0.05) reduced the dilation of the inner
       diameter of left ventricle (LV) (4.27±0.29 mm), increased wall
       thickness of LV (1.5±0.13 mm) andimproved the fractional
       shortening of LV of hearts (LVFS) (42.8±2.4%) compared with
       those values of LVs of rats without implants (MI group) (e.g.,
       5.92±0.39 mm, 1.2±0.06 mm and 31.5±1.4%, respectively).
       [font=verdana][size=small]Moreover, blood vessel-like structures
       in MI regions of LVs in the CHS group were widely distributed
       [/font][font=verdana]while none was found in the MI group. The
       CHS group significantly improved the secretion of paracrine
       [/font][font=verdana]factors, such as VEGF in the MI regions of
       LVs (P<0.05, n=4), relative to that in the MI group. In
       conclusion, [/font][font=verdana]chitosan-HYA/SF cardiac patches
       are promising biomaterials for the cardiac repair of MI rat
       hearts.
       [/font]
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  HTML http://www.uplooder.net/cgi-bin/dl.cgi?key=971a59d8f942022b3aac6faf76af6452[/center]
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