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DIR Return to: Cardiovascular Tissue Engineering
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#Post#: 86--------------------------------------------------
Cardiac repair using chitosan-hyaluronan/silk fibroin patches
DIR By: SSamani
Date: February 21, 2015, 1:36 pm
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[center]Cardiac repair using chitosan-hyaluronan/silk fibroin
patches in a rat heart model with myocardial infarction
Carbohydrate Polymers 92 (2013) 591– 597[/center]
Abstract
The cardiac repair of myocardial infarction (MI) hearts of rats
using chitosan-hyaluronan/silk fibroin (chitosan-HYA/SF) cardiac
patches was examined after eight weeks of implantation. Rats
with implantations of chitosan-HYA/SF patches (CHS group)
significantly (P <0.05) reduced the dilation of the inner
diameter of left ventricle (LV) (4.27±0.29 mm), increased wall
thickness of LV (1.5±0.13 mm) andimproved the fractional
shortening of LV of hearts (LVFS) (42.8±2.4%) compared with
those values of LVs of rats without implants (MI group) (e.g.,
5.92±0.39 mm, 1.2±0.06 mm and 31.5±1.4%, respectively).
[font=verdana][size=small]Moreover, blood vessel-like structures
in MI regions of LVs in the CHS group were widely distributed
while none was found in the MI group. The CHS group
significantly improved the secretion of paracrine factors, such
as VEGF in the MI regions of LVs (P<0.05, n=4), relative to that
in the MI group. In conclusion, chitosan-HYA/SF cardiac patches
are promising biomaterials for the cardiac repair of MI rat
hearts.
[center]Download link
HTML http://www.uplooder.net/cgi-bin/dl.cgi?key=971a59d8f942022b3aac6faf76af6452[/center]
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