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       #Post#: 71--------------------------------------------------
       Schwann cell response on polypyrrole substrates
   DIR By: SSamani
       Date: January 30, 2015, 11:44 pm
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       Schwann cell response on polypyrrole substrates upon electrical
       stimulation
  HTML http://www.ncbi.nlm.nih.gov/pubmed/24512979
       Forciniti L, Ybarra J 3rd, Zaman MH, Schmidt CE
       Current injury models suggest that Schwann cell (SC) migration
       and guidance are necessary for successful regeneration and
       synaptic reconnection after peripheral nerve injury. The ability
       of conducting polymers such as polypyrrole (PPy) to exhibit
       chemical, contact and electrical stimuli for cells has led to
       much interest in their use for neural conduits. Despite this
       interest, there has been very little research on the effect that
       electrical stimulation (ES) using PPy has on SC behavior. Here
       we investigate the mechanism by which SCs interact with PPy in
       the presence of an electric field. Additionally, we explored the
       effect that the adsorption of different serum proteins on PPy
       upon the application of an electric field has on SC migration.
       The results indicate an increase in average displacement of the
       SC with ES, resulting in a net anodic migration. Moreover,
       indirect effects of protein adsorption due to the oxidation of
       the film upon the application of ES were shown to have a larger
       effect on migration speed than on migration directionality.
       These results suggest that SC migration speed is governed by an
       integrin- or receptor-mediated mechanism, whereas SC migration
       directionality is governed by electrically mediated phenomena.
       These data will prove invaluable in optimizing conducting
       polymers for their different biomedical applications such as
       nerve repair.
       Acta Biomaterialia 10 (2014) 2423–2433
  HTML http://dx.doi.org/10.1016/j.actbio.2014.01.030
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