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       #Post#: 47--------------------------------------------------
       Collagen/chitosan porous scaffolds for skin tissue engineering
       By: fmsbi Date: December 25, 2014, 6:46 pm
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       [center]Collagen/chitosan porous scaffolds with improved
       biostability for skin tissue engineering[/center]
       Lie Maa, Changyou Gaoa, , , Zhengwei Maoa, Jie Zhoua, Jiacong
       Shena, Xueqing Hub, Chunmao Hanb
       Porous scaffolds for skin tissue engineering were fabricated by
       freeze-drying the mixture of collagen and chitosan solutions.
       Glutaraldehyde (GA) was used to treat the scaffolds to improve
       their biostability. Confocal laser scanning microscopy
       observation confirmed the even distribution of these two
       constituent materials in the scaffold. The GA concentrations
       have a slight effect on the cross-section morphology and the
       swelling ratios of the cross-linked scaffolds. The collagenase
       digestion test proved that the presence of chitosan can
       obviously improve the biostability of the collagen/chitosan
       scaffold under the GA treatment, where chitosan might function
       as a cross-linking bridge. A detail investigation found that a
       steady increase of the biostability of the collagen/chitosan
       scaffold was achieved when GA concentration was lower than 0.1%,
       then was less influenced at a still higher GA concentration up
       to 0.25%. In vitro culture of human dermal fibroblasts proved
       that the GA-treated scaffold could retain the original good
       cytocompatibility of collagen to effectively accelerate cell
       infiltration and proliferation. In vivo animal tests further
       revealed that the scaffold could sufficiently support and
       accelerate the fibroblasts infiltration from the surrounding
       tissue. Immunohistochemistry analysis of the scaffold embedded
       for 28 days indicated that the biodegradation of the 0.25%
       GA-treated scaffold is a long-term process. All these results
       suggest that collagen/chitosan scaffold cross-linked by GA is a
       potential candidate for dermal equivalent with enhanced
       biostability and good biocompatibility.
  HTML http://www.sciencedirect.com/science/article/pii/S0142961203003740
  HTML http://www.sciencedirect.com/science/article/pii/S0142961203003740
       #Post#: 48--------------------------------------------------
       Re: Collagen/chitosan porous scaffolds for skin tissue engineeri
       ng
       By: SSamani Date: December 26, 2014, 12:37 am
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       Hi
       Hyperlink was broken. ???
       Download full article.
       Thanks
       [center]Download link
  HTML http://www.uplooder.net/cgi-bin/dl.cgi?key=aa26c2b893ed70bc8f95d71e968f4d68[/center]
       #Post#: 53--------------------------------------------------
       Re: Collagen/chitosan porous scaffolds for skin tissue engineeri
       ng
       By: fmsbi Date: December 26, 2014, 8:49 am
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