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#Post#: 45--------------------------------------------------
skeletal muscle tissue engineering
By: fmsbi Date: December 25, 2014, 6:39 pm
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[center]Current opportunities and challenges in skeletal muscle
tissue engineering (Review)[/center]
Koning, M.ab, Harmsen, M.C.b, Van Luyn, M.J.A.b, Werker, P.M.N.a
a Department of Plastic Surgery, University Medical Centre
Groningen, University of Groningen, Netherlands
b Department of Pathology and Medical Biology, University
Medical Centre Groningen, University of Groningen, Netherlands
Abstract
The purpose of this article is to give a concise review of the
current state of the art in tissue engineering (TE) of skeletal
muscle and the opportunities and challenges for future clinical
applicability. The endogenous progenitor cells of skeletal
muscle, i.e. satellite cells, show a high proneness to muscular
differentiation, in particular exhibiting the same
characteristics and function as its donor muscle. This suggests
that it is important to use an appropriate progenitor cell,
especially in TE facial muscles, which have a exceptional
anatomical and fibre composition compared to other skeletal
muscle. Muscle TE requires an instructive scaffold for
structural support and to regulate the proliferation and
differentiation of muscle progenitor cells. Current literature
suggests that optimal scaffolding could comprise of a fibrin gel
and cultured monolayers of muscle satellite cells obtained
through the cell sheet technique. Tissue-engineered muscle
constructs require an adequate connection to the vascular system
for efficient transport of oxygen, carbon dioxide, nutrients and
waste products. Finally, functional and clinically applicable
muscle constructs depend on adequate neuromuscular junctions
with neural cells. To reach this, it seems important to apply
optimal electrical, chemotropic and mechanical stimulation
during engineering and discover other factors that influence its
formation. Thus, in addition to approaches for myogenesis, we
discuss the current status of strategies for angiogenesis and
neurogenesis of TE muscle constructs and the significance for
future clinical use. Copyright © 2009 John Wiley & Sons, Ltd.
#Post#: 50--------------------------------------------------
Re: skeletal muscle tissue engineering
By: SSamani Date: December 26, 2014, 12:49 am
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Hi
Download full article.
Thanks
[center]Download link
HTML http://www.uplooder.net/cgi-bin/dl.cgi?key=48dea3066b0e7081296194beef324511[/center]
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