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       #Post#: 44--------------------------------------------------
       Electrospun nanofiber-based regeneration of cartilage
       By: fmsbi Date: December 25, 2014, 6:33 pm
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       Application of biomaterials in combination with stem cells is a
       novel tissue engineering approach to regenerate cartilage. The
       objective of this study was to investigate the potential of
       poly(vinyl alcohol)/polycaprolactone (PVA/PCL) nanofiber
       scaffolds seeded with rabbit bone marrow-mesenchymal stem cell
       (BM-MSC) for cartilage tissue engineering in vitro and in vivo.
       We tested the biocompatibility and mechanical properties of
       nanofibrous scaffolds using scanning electron microscope, MTT
       assay, and tensile measurements. The capacity of MSC for
       chondrogenic differentiation on scaffolds was examined using
       reverse transcription-polymer chain reaction and immunostaining.
       For in vivo assessments, PVA/PCL nanofiber scaffolds with or
       without MSC were implanted into rabbit full-thickness cartilage
       defects. To evaluate cartilage regeneration, semi-quantitative
       grading and histological analysis were performed. Our results
       showed that PVA/PCL scaffolds supported the proliferation and
       chondrogenic differentiation of MSC in vitro. Moreover, the
       animals treated with cell-seeded PVA/PCL scaffolds showed
       improved healing of defects compared with untreated control and
       those which received cell-free scaffolds. Our findings suggest
       that PVA/PCL scaffolds incorporated with MSC can serve as a
       suitable graft for articular cartilage reconstruction. © 2011
       Wiley Periodicals, Inc. J Biomed Mater Res Part A: 99A:467–467,
       2011.
       #Post#: 54--------------------------------------------------
       Re: Electrospun nanofiber-based regeneration of cartilage
       By: SSamani Date: December 26, 2014, 12:35 pm
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       Hi
       The article was shrunk to reduce size.
       Yours
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