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#Post#: 43--------------------------------------------------
Articular cartilage repair
By: fmsbi Date: December 25, 2014, 6:30 pm
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This review paper cited by more than 900 paper
[center]Articular cartilage repair: Basic science and clinical
progress. A review of the current status and prospects
(Review)[/center]
Hunziker, E.B.
M.E. Müller-Institute for Biomechanics, University of Bern,
Murtenstrasse 35, CH-3010, Bern, Switzerland
Abstract
Objective: To review the basic scientific status of repair in
articular cartilage tissue and to assess the efficiency of
current clinical therapies instigated for the treatment of
structural lesions generated therein as a result of trauma or
during the course of various diseases, notably osteoarthritis
(OA). Current scientific trends and possible directions for the
future will also be discussed. Design: A systematic and critical
analysis is undertaken, beginning with a description of the
spontaneous repair responses in different types of lesion.
Surgical interventions aimed at inducing repair without the use
of active biologics will then be considered, followed by those
involving active biologics and those drawing on autogenic and
allogeneic tissue transplantation principles. Cell
transplantation approaches, in particular novel tissue
engineering concepts, will be critically presented. These will
include growth-factor-based biological treatments and gene
transfection protocols. A number of technical problems
associated with repair interventions, such as tissue
integration, tissue retention and the role of mechanical
factors, will also be analysed. Results: A critical analysis of
the literature reveals the existence of many novel and very
promising biologically-based approaches for the induction of
articular cartilage repair, the vast majority of which are still
at an experimental phase of development. But prospective,
double-blinded clinical trials comparing currently practiced
surgical treatments have, unfortunately, not been undertaken.
Conclusion: The existence of many new and encouraging biological
approaches to cartilage repair justifies the future investment
of time and money in this research area, particularly given the
extremely high socio-economic importance of such therapeutic
strategies in the prevention and treatment of these common joint
diseases and traumas. Clinical epidemiological and prospective
trials are, moreover, urgently needed for an objective,
scientific appraisal of current therapies and future novel
approaches. © 2002 OsteoArthritis Research Society
International. Published by Elsevier Science Ltd. All rights
reserved.
#Post#: 51--------------------------------------------------
Re: Articular cartilage repair
By: SSamani Date: December 26, 2014, 1:10 am
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Hi
Download full article.
Thanks
[center]Download link
HTML http://www.uplooder.net/cgi-bin/dl.cgi?key=4df44342ffc74a805b87702e74062253[/center]
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