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   DIR Return to: Peripheral Nervous system and Tissue Engineering
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       #Post#: 33--------------------------------------------------
       Comparative Study between Fibrin Scaffold and Autograft in Sciat
       ic Nerve Repair:
       By: nourani Date: December 17, 2014, 9:22 pm
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       Background: Autograft is the golden standard approach in
       reconstruction of peripheral nerve injuries. However, due to
       limited accessibility to autograft and the high risk of neuroma
       formation, an alternative repair method is the target of many
       investigations. The objective of the present study was to
       investigate the effect of using fibrin scaffold (FS) in
       repairing injured sciatic nerve in rats.
       Materials and Methods: Forty five male Wistar rats weighing
       200-250g were randomly divided into three groups: control,
       autograft (A) and fibrin scaffold (FS). The 5mm cut in right
       sciatic nerve was repaired with autograft and FS in A and FS
       groups. Animals were then assessed by behavioral and EMG tests
       in one, three and five weeks following the induced injury.
       Results were then compared in three groups using one way ANOVA
       Results: The obtained data in the first, 3rd and the 5th weeks
       after the recovery showed no significant difference between
       experimental groups, but there was a significant difference
       between experimental groups and the control group. The mean
       functional index of the sciatic nerve was in parallel in both
       experimental groups throughout the five weeks of follow-up
       period. The mean motor response delay had a similar trend and
       was not significantly different in experimental groups. So was
       the amplitude of the mean motor action potential.
       Conclusion: The presented data are in favor of the notion that
       the fibrin scaffold could potentially be considered as an
       alternative approach for autograft transplants in peripheral
       nerve injuries.
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